Evidence map›Paper›PMID 39935900›Full record

ArticleInternational journal of sexual health : official journal of the World Association for Sexual Health2025

Evaluation of the Efficacy and Safety of On-Demand Tadalafil Alone or Combined With Lidocaine Spray for Treating Patients With Comorbid Erectile Dysfunction and Premature Ejaculation: A Randomized Controlled Trial.

Min Liu, Zi Xiang Deng, Xianxiang Zhu, ShiAn Hu

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In one paragraph

Article in International journal of sexual health : official journal of the World Association for Sexual Health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Min LiuDepartment of Reproductive Medicine, The First Affiliated Hospital of Gannan Medical University, Ganzhou City, China.ORCID https://orcid.org/0009-0000-7793-2496
Zi Xiang DengDepartment of Nephrology, The First Affiliated Hospital of Gannan Medical University, Ganzhou City, China.ORCID https://orcid.org/0009-0003-7042-7165
Xianxiang ZhuDepartment of Nephrology, The First Affiliated Hospital of Gannan Medical University, Ganzhou City, China.ORCID https://orcid.org/0009-0000-7376-6187
ShiAn HuGannan Medical University, Gannan Medical College, Ganzhou, China.ORCID https://orcid.org/0009-0001-0592-8153

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: To evaluate the efficacy and safety of on-demand 20 mg tadalafil alone or combined with lidocaine spray for treating patients with comorbid erectile dysfunction (ED) and premature ejaculation (PE). Methods: This randomized controlled trial included 98 patients with comorbid ED and PE, randomly assigned to the experimental group ( Results: Both groups showed significant improvement in IIEF-5 scores, but the difference between groups was not significant ( Conclusion: Tadalafil combined with lidocaine spray is superior to tadalafil alone in improving symptoms, prolonging IELT, and enhancing sexual satisfaction in patients with comorbid ED and PE, with comparable safety. This combination therapy provides a new approach for improving treatment strategies for patients with comorbid ED and PE. Large-scale, multi-center randomized controlled trials are needed to further validate these findings.

Indexed as

Erectile dysfunctionlidocaine spraypremature ejaculationrandomized controlled trialtadalafil

Identifiers

PMID39935900
PMCPMC11810077

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.