ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Validity of one-time assessments for identifying prodromal Alzheimer's disease in adults with Down syndrome.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Circadian Rest-Activity Rhythms, Cognition, and Alzheimer Disease Dementia in Adults With Down Syndrome.Neurology · 2026Article
- Adaptive and Maladaptive Behaviours and Their Cognitive Correlates in Aging Adults With Down Syndrome.Journal of applied research in intellectual disabilities : JARID · 2026Article
- Validity of one-time assessments for identifying prodromal Alzheimer's disease in adults with Down syndrome.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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9 authors.
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Abstract
Introduction: New Alzheimer's disease (AD) treatments have created an urgent need for accurate early diagnosis of high-risk adults with Down syndrome (DS), distinguishing prodromal DS-AD symptoms from lifelong cognitive impairments. Often, clinicians will need to evaluate dementia status during a single assessment, and here we describe empirically supported methods effective under such circumstances. Methods: Archived data collected between 1987 and 2017 included longitudinal findings for 144 individuals maintaining cognitive stability and 126 developing prodromal DS-AD. Response operating characteristic analyses compared groups, defined by the presence/absence of prodromal DS-AD, for a single assessment. Results: Groups differed on all measures without adjusting for developmental history, 0.717 < areas under the curve < 0.859, Discussion: The present study demonstrated that one-time assessments can inform clinical judgments when diagnosing adults at risk for DS-AD. Knowledge of developmental history is valuable but non-essential. Highlights: Non-overlapping distributions were observed for preclinical and prodromal Alzheimer's disease (AD) groups.Receiver operating characteristic area under the curve analyses were in the acceptable to excellent range for all measures.Performance was sensitive to both the severity of intellectual disability and the stage of Down syndrome-AD progression.Episodic memory tests were sensitive to the transition from preclinical to prodromal AD.Performance results at a single time point can inform dementia status decisions.
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