Evidence map›Paper›PMID 39935887›Full record

ArticlebioRxiv : the preprint server for biology2025

Dynamic global acetylation remodeling during the yeast heat shock response.

Rebecca E Hardman-Kavanaugh, Aaron J Storey, Tara N Stuecker, Stephanie E Hood, Gregory A Barrett-Wilt, Venkata R Krishnamurthi, Yong Wang, Stephanie D Byrum, Samuel G Mackintosh, Rick D Edmondson and 3 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Rebecca E Hardman-KavanaughInterdisciplinary Graduate Program in Cell and Molecular Biology, University of Arkansas, Fayetteville, Arkansas 72701, United States of America.
Aaron J StoreyDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, United States of America.
Tara N StueckerDepartment of Biological Sciences, University of Arkansas, Fayetteville, Arkansas 72701, United States of America.
Stephanie E HoodDepartment of Biological Sciences, University of Arkansas, Fayetteville, Arkansas 72701, United States of America.ORCID 0000-0002-9857-5392
Gregory A Barrett-WiltBiotechnology Center, University of Wisconsin, Madison, WI, 53706, United States of America.ORCID 0000-0002-3583-8642
Venkata R KrishnamurthiDepartment of Physics, University of Arkansas, Fayetteville 72701, AR, United States of America.
Yong WangInterdisciplinary Graduate Program in Cell and Molecular Biology, University of Arkansas, Fayetteville, Arkansas 72701, United States of America.
Stephanie D ByrumDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, United States of America.ORCID 0000-0002-1783-3610
Samuel G MackintoshDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, United States of America.
Rick D EdmondsonCollege of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, United States of America.
Wayne P WahlsDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, United States of America.ORCID 0000-0002-1338-1610
Alan J TackettDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, United States of America.ORCID 0000-0002-3672-4460
Jeffrey A LewisDepartment of Biological Sciences, University of Arkansas, Fayetteville, Arkansas 72701, United States of America.ORCID 0000-0003-2952-9701

Funding

Understanding Hesitant AdoptersP20GM103429 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Lawrence E Cornett, JERRY WARE · 2012 to 2026
$60.9M
Translational Regulation in Normal Erythropoiesis and Diamond Blackfan AnemiaP20GM121293 · NIGMS · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI Alan Tackett, Sean D. Taverna · 2017 to 2026
$27.6M
Supplement for Google cloud build-outR24GM137786 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Alan Tackett · 2020 to 2026
$15.4M
Biochemistry of recombination in meiosisR01GM081766 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI WAHLS, WAYNE P · 2007 to 2018
$2.5M
Melanoma Resistance Evolution Atlas (MREA) for identifying combinatorial targets to prevent and reverse MAPKi resistanceR01CA282198 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROGER S LO, Alan Tackett · 2024 to 2026
$2.0M
Systematic elucidation of DNA sequence codes that regulate meiotic recombinationR01GM145834 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI WAHLS, WAYNE P · 2022 to 2025
$1.7M
NCI NIH HHS R01 CA282198NIGMS NIH HHS P20 GM103429NIGMS NIH HHS P20 GM121293NIGMS NIH HHS R01 GM081766NIGMS NIH HHS R01 GM145834NIGMS NIH HHS R24 GM137786
6 · The paper itself

Abstract

All organisms experience stress and must rapidly respond to changing conditions. Thus, cells have evolved sophisticated rapid-response mechanisms such as post-translational protein modification to rapidly and reversibly modulate protein activity. One such post-translational modification is reversible lysine acetylation, where proteomic studies have identified thousands of acetylated proteins across diverse organisms. While the sheer size of the 'acetylome' is striking, the function of acetylation for the vast majority of proteins remains largely obscure. Here, we show that global acetylation plays a previously unappreciated role in the heat shock response of

Identifiers

PMID39935887
PMCPMC11812598

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.