Evidence map›Paper›PMID 39935870›Full record

ArticleFrontiers in aging neuroscience2025

Hypertension moderates the relationship between plasma beta-amyloid and cognitive impairment: a cross-sectional study in Xi'an, China.

Ziyu Liu, Yaoli He, Simeng Cui, Liangjun Dang, Binyan Zhang, Jin Wang, Wenhui Lu, Kang Huo, Yu Jiang, Chen Chen and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Ziyu Liu *Department of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Yaoli He *Department of Neurology, Baoji Central Hospital, Baoji, China.
Simeng CuiDepartment of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Liangjun DangDepartment of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Binyan ZhangDepartment of Epidemiology and Health Statistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Jin WangDepartment of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Wenhui LuDepartment of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Kang HuoDepartment of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Yu JiangDepartment of Neurology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Chen ChenDepartment of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Ling GaoDepartment of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Shan WeiDepartment of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Yi ZhaoDepartment of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Ningwei HuDepartment of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Jingyi WangDepartment of Neurology, Huyi Hospital of Traditional Chinese Medicine, Xi'an, China.
Hong LvDepartment of Neurology, The First Affiliated Hospital of China Medical University, Shenyang, China.
Qiumin QuDepartment of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Suhang ShangDepartment of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Plasma beta-amyloid (Aβ) are important biomarkers for Alzheimer's disease and cognitive impairment (CI), but results are controversial. It remains unclear whether hypertension modulates their relationship. This cross-sectional study investigates whether hypertension moderates the relationship between plasma Aβ and cognitive impairment (CI). Methods: This cross-sectional study included 1488 subjects ≥ 40 years from rural areas of northwestern China. CI was defined as a Mini-Mental State Examination score lower than the cutoff. Firstly, plasma Aβ Results: 737 participants (49.5%) had hypertension and 189 participants (12.7%) had CI. Simultaneously elevated plasma Aβ Conclusion: Hypertension is an important modulator in the relationship between plasma Aβ and CI. Simultaneously elevated plasma Aβ

Indexed as

a cross-sectional studyAlzheimer’s diseasebeta-amyloidcognitive impairmenthypertension

Identifiers

PMID39935870
PMCPMC11810958

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