Evidence map›Paper›PMID 39935824›Full record

ReviewBiological psychiatry global open science2025

Mental Health Across the Metabolic Spectrum.

Vrinda Saxena, Isaac Marin-Valencia

Abstract readReview
In one paragraph

Review in Biological psychiatry global open science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Vrinda SaxenaDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York.
Isaac Marin-ValenciaDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York.

Funding

Mechanisms and Therapies for Cerebellar Development Under Defective Mitochondrial MetabolismK08NS110877 · NINDS · ROCKEFELLER UNIVERSITY · PI MARIN-VALENCIA, ISAAC · 2019 to 2023
$999k
A New Therapy for Neurodevelopmental Mitochondrial DisordersR21NS133826 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MARIN-VALENCIA, ISAAC · 2024 to 2025
$211k
Universal Database for Neurometabolic DiseasesR03NS137124 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MARIN-VALENCIA, ISAAC · 2024 to 2024
$169k
NINDS NIH HHS K08 NS110877NINDS NIH HHS R03 NS137124NINDS NIH HHS R21 NS133826
6 · The paper itself

Abstract

Understanding the relationship between metabolism and mental health involves examining how disruptions in one system influence the other. The specific mechanisms by which metabolic processes impact the mind-and how mental well-being, in turn, affects metabolic regulation-are poorly understood. This shortcoming is attributable to the complex and multilayered nature of both the metabolic network and mental processes, as well as the lack of robust quantitative methods to analyze the workings of the mind. Inborn errors of metabolism exemplify this complexity, with over one-fourth being associated with psychiatric manifestations. Despite their high prevalence, psychiatric deficits in individuals with inborn errors of metabolism remain challenging to recognize and manage due to phenotypic variability, limited clinical training in neurometabolism, and gaps in research. To identify intersections between metabolism and mental health, here we assessed the effects of metabolic dysregulation on mental function, focusing on inborn errors of metabolism.

Indexed as

Inborn errors of metabolismMentalMetabolismNeurodegenerationNeurodevelopmentPsychiatry

Identifiers

PMID39935824
PMCPMC11810702

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.