Evidence map›Paper›PMID 39935805›Full record

ReviewFrontiers in neurology2024

Impact of physical exercise on the regulation of brain-derived neurotrophic factor in people with neurodegenerative diseases.

Ana Romero Garavito, Valery Díaz Martínez, Estherz Juárez Cortés, José Vicente Negrete Díaz, Liliana Marcela Montilla Rodríguez

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07625163 (The Effects of Aerobic Exercise and Mindful Breathing on Symptom Severity and Quality of Life in Individuals With Major Depressive Disorder in Saudi Arabia), which is not on this map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07625163 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

The Effects of Aerobic Exercise and Mindful Breathing on Symptom Severity and Quality of Life in Individuals With Major Depressive Disorder in Saudi Arabia: A Randomised Clinical Trial Protocol

TypeinterventionalSponsorUniversity of PretoriaRan2026 to 2026Enrolled60ConditionsMajor Depressive Disorder (MDD)ArmsAerobic exercise, Mindful Breathing
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  17. BDNF-amyloid-Frontiers in molecular neuroscience · 2026
    Review
  18. Review
  19. Article
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ana Romero GaravitoFacultad de medicina, Universidad Cooperativa de Colombia, Villavicencio, Colombia.
Valery Díaz MartínezFacultad de medicina, Universidad Cooperativa de Colombia, Villavicencio, Colombia.
Estherz Juárez CortésPrograma de Fisioterapia, Universidad de Guanajuato, Guanajuato, Mexico.
José Vicente Negrete DíazPrograma de Fisioterapia, Universidad de Guanajuato, Guanajuato, Mexico.
Liliana Marcela Montilla RodríguezFacultad de medicina, Universidad Cooperativa de Colombia, Villavicencio, Colombia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review explores the impact of physical exercise on brain-derived neurotrophic factor (BDNF) and its relationship with neurodegenerative diseases. The key role of BDNF in maintaining brain health is highlighted, and recent studies are analyzed that indicate an increase in BDNF levels following physical activity, particularly in young adults. Additionally, the interaction between the BDNF Val66Met genetic polymorphism and exercise on cognitive function is examined. The review emphasizes the possibility of exercise as a complementary therapy for neurodegenerative diseases, although further research is required to fully understand its effects.

Indexed as

brain-derived neurotrophic factor (BDNF)dementianeurodegenerative diseasesneuroplasticityParkinson’s diseasephysical exercise

Identifiers

PMID39935805
PMCPMC11810746

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.