Evidence map›Paper›PMID 39935763›Full record

ArticleHuman reproduction open2025

Now is the time to introduce new innovative assisted reproduction methods to implement accessible, affordable, and demonstrably successful advanced infertility services in resource-poor countries.

Willem Ombelet, Jonathan Van Blerkom, Gerhard Boshoff, Carin Huyser, Federica Lopes, Geeta Nargund, Hassan Sallam, Koen Vanmechelen, Rudi Campo

Abstract readEditorial
In one paragraph

Article in Human reproduction open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Willem OmbeletThe Walking Egg Non-Profit Organization, Genk, Belgium.ORCID https://orcid.org/0000-0002-7206-1537
Jonathan Van BlerkomDepartment of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO, USA.
Gerhard BoshoffFaculty of Medicine and Life Sciences, LCRC, University of Hasselt, Diepenbeek, Belgium.
Carin HuyserDepartment of Obstetrics and Gynaecology, University of Pretoria, Pretoria, South Africa.
Federica LopesSchool of Medicine, University of Dundee, Dundee, UK.
Geeta NargundSt George's Hospital NHS Trust, London, UK.
Hassan SallamDepartment of Reproductive Medicine, Alexandria University Faculty of Medicine, Alexandria, Egypt.
Koen VanmechelenThe Walking Egg Non-Profit Organization, Genk, Belgium.
Rudi CampoThe Walking Egg Non-Profit Organization, Genk, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nearly 200 million people worldwide suffer from infertility. Disparities exist between developed and developing countries due to differences in the availability of infertility care, different reimbursement policies and socio-cultural differences surrounding procreation. In low- and middle-income countries, specialized infertility centres are either scarce or non-existent, mostly in private settings, and accessible only to the fortunate few who can afford them. The success and sustainability of ARTs will depend on our ability to optimize these techniques in terms of availability, affordability, and effectiveness. A low-cost, simplified IVF system has been developed and shown to be safe, cost-effective, and widely applicable to low-resource settings. Combined with inexpensive mild ovarian stimulation protocols, this could become a truly effective means of treating infertility and performing assisted reproduction at affordable prices, but only if such programmes are sincerely desired and supported by all relevant stakeholders. A receptive political, governmental, and clinical community is essential.

Indexed as

accessibleaffordableassisted reproductioninfertility careLMICslow- and middle-income countriessimplified IVF

Identifiers

PMID39935763
PMCPMC11810638

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.