Evidence map›Paper›PMID 39935747›Full record

ArticleDEN open2025

Influence of antiplatelet drugs on gastric ulcer healing after endoscopic submucosal dissection in patients with early gastric cancer.

Kazuto Takahashi, Takuto Nosaka, Yosuke Murata, Ryotaro Sugata, Yu Akazawa, Tomoko Tanaka, Tatsushi Naito, Hidetaka Matsuda, Masahiro Ohani, Hiroyuki Suto and 1 more

Abstract read
In one paragraph

Article in DEN open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kazuto TakahashiSecond Department of Internal Medicine, Faculty of Medical Sciences University of Fukui Fukui Japan.ORCID https://orcid.org/0000-0003-4952-8714
Takuto NosakaSecond Department of Internal Medicine, Faculty of Medical Sciences University of Fukui Fukui Japan.
Yosuke MurataSecond Department of Internal Medicine, Faculty of Medical Sciences University of Fukui Fukui Japan.
Ryotaro SugataSecond Department of Internal Medicine, Faculty of Medical Sciences University of Fukui Fukui Japan.
Yu AkazawaSecond Department of Internal Medicine, Faculty of Medical Sciences University of Fukui Fukui Japan.ORCID https://orcid.org/0000-0002-8030-7373
Tomoko TanakaSecond Department of Internal Medicine, Faculty of Medical Sciences University of Fukui Fukui Japan.ORCID https://orcid.org/0000-0002-5768-3805
Tatsushi NaitoSecond Department of Internal Medicine, Faculty of Medical Sciences University of Fukui Fukui Japan.
Hidetaka MatsudaDepartment of Gastroenterology Fukui General Hospital Fukui Japan.
Masahiro OhaniSecond Department of Internal Medicine, Faculty of Medical Sciences University of Fukui Fukui Japan.
Hiroyuki SutoDepartment of Gastroenterology Fukui Katsuyama General Hospital Fukui Japan.
Yasunari NakamotoSecond Department of Internal Medicine, Faculty of Medical Sciences University of Fukui Fukui Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: The causes of drug-induced gastroduodenal injuries primarily include antithrombotic drugs, including low-dose aspirin, non-steroidal anti-inflammatory drugs, and corticosteroids. These drugs are suspected to affect gastric ulcer healing after endoscopic submucosal dissection (ESD). This study aimed to investigate the effects of these drugs on post-ESD ulcer healing. Methods: This study included 170 lesions (149 patients) who had undergone ESD for early gastric cancer. Post-ESD ulcers were endoscopically measured on the 1st, 28th, and 56th days after ESD and were analyzed to identify potential risk factors for delayed ulcer healing among patients taking antiplatelet drugs, anticoagulant drugs, non-steroidal anti-inflammatory drugs, corticosteroids, and no drugs. Results: Multivariate analysis for the frequency of scarring on the 56 Conclusions: As antiplatelet drugs, particularly clopidogrel, may delay gastric ulcer healing after ESD, careful endoscopic follow-up and drug therapy are suggested for patients taking these drugs.

Indexed as

aspirinclopidogrelendoscopic submucosal dissectionplatelet aggregation inhibitorsstomach ulcer

Identifiers

PMID39935747
PMCPMC11811763

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.