ArticleFrontiers in neurology2025
Cross-sectional study on the association between neutrophil-percentage-to-albumin ratio (NPAR) and prevalence of stroke among US adults: NHANES 1999-2018.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Association between neutrophil percentage-to-albumin ratio and vascular cognitive impairment in patients with cerebrovascular disease: a cross-sectional study.BMC neurology · 2026Trial
- Association Between Neutrophil Percentage-Albumin Ratio and Biological Aging in Rheumatoid Arthritis in the United States: A Cross-Sectional Study of NHANES.Mediators of inflammation · 2026Article
- Correlation of neutrophil- and high-density lipoprotein cholesterol-related inflammatory markers with sarcopenia: Insights from a cross-sectional study.The Journal of international medical research · 2026Article
- Article
- A comprehensive evaluation of the associations between 12 composite inflammatory indices and all-cause mortality after stroke: a multicohort study.Frontiers in aging neuroscience · 2025Article
- Higher Neutrophil-Percentage-to-Albumin Ratio Was Associated with Poor Outcome in Endovascular Thrombectomy Patients.Therapeutics and clinical risk management · 2025Article
- Association of neutrophil-percentage-to-albumin ratio with mortality in older stroke survivors.Frontiers in aging neuroscience · 2025Article
- Prognostic value of the neutrophil percentage-to-albumin ratio for mortality in ICU patients with myocardial infarction: a retrospective cohort and machine learning analysis.Frontiers in cardiovascular medicine · 2025Article
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13 authors.
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Abstract
The neutrophil-to-albumin ratio (NPAR) is a relatively novel composite biomarker of inflammation, which has been used for prognostication in cardiovascular diseases and may also be associated with stroke. A cross-sectional analysis was conducted using data from the National Health and Nutrition Examination Survey (NHANES) 1999-2018, including 48,734 individuals with complete NPAR and stroke data. The association between stroke prevalence and NPAR values was assessed through multivariate regression analysis. The relationship between these variables was further visualized using restricted cubic splines (RCS). Additionally, potential factors influencing this relationship were explored through subgroup analysis. The regression model revealed a significant association between NPAR and stroke prevalence, even after adjusting for other covariates [1.06 (1.04, 1.08)]. Stroke prevalence was 62% higher in the highest NPAR group compared to the lowest [1.62 (1.40, 1.89)]. The RCS analysis further confirmed this positive correlation. Subgroup analysis showed that this association was not significantly influenced by other factors. This study establishes a strong association between NPAR and stroke prevalence. However, further studies are needed to clarify the underlying mechanisms and establish a direct causal link.
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