ArticleThe journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG2025
Neurodevelopmental Outcome at 20 Months Corrected Age in Extremely Preterm Infants After Exposure to Dexamethasone and Hydrocortisone in the NICU.
Article in The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Secondary Pharmacology Targets for Pediatric Developmental Safety Assessment of New Drugs: Clinical Pharmacology Considerations.Clinical pharmacology and therapeutics · 2026Review
- Optimal postnatal corticosteroid regimens to prevent bronchopulmonary dysplasia with minimal adverse effects.Clinical and experimental pediatrics · 2026Article
- Do Postnatal Corticosteroids Negatively Impact the Neurodevelopmental Outcomes of Extremely Preterm Infants?The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2025Article
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Authors and funding
6 authors.
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Abstract
objectiveTo evaluate the association between hydrocortisone (HC) and dexamethasone (DEX) exposure in the NICU on neurodevelopmental (ND) outcome in extremely preterm (EPT; GA <28 weeks) infants.
methodsThis is a single-center retrospective cohort chart review of EPT infants born between 2011 to 2016 compared in terms of ND outcome at 20 months corrected age (CA). Steroid exposures, sociodemographic factors and neonatal comorbidities were collected. Outcome measures included neurologic exam and -Bayley-3 testing. Multiple regression analyses adjusted for effects of risk factors on outcome.
resultsOf the 221/264 survivors, 138 had no steroid exposure, 47 received HC only and 36 received DEX ± HC. Steroid-exposed groups were of lower birth weight and gestational age and had higher rates of neonatal comorbidities. Total duration and cumulative dosage of HC was not significantly different between steroid-exposed groups. Infants exposed to DEX ± HC had significantly lower Bayley-3 indices as compared with the no-steroid and HC only group. In linear regression analyses, DEX ± HC was associated with a 10-point reduction in cognitive (p < 0.01), language (p < 0.05), and motor (p < 0.01) indices.
conclusionsIn EPT infants, prolonged, repeated steroid exposure with DEX ± HC was associated with adverse cognitive, language and motor outcomes at 20 months CA. Further research may expose the -cumulative effect of steroids in this vulnerable population.
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