ArticleFrontiers in cellular and infection microbiology2024
Transcriptional profiles analysis of effects of
Article in Frontiers in cellular and infection microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Association of Some Pro-and Anti-Inflammatory Cytokines Response Pattern against Toxoplasmosis in Newly Married Couples.Iranian journal of parasitologyArticle
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Methods: To investigate the mechanism of action of gonococcal ROP16 proteins in human macrophages, we constructed a lentivirus overexpressing ROP16 and established stably transfected cell lines. We then analyzed the gene transcriptional profiles of ROP16 II in THP-1 macrophages using transcriptome sequencing. Interaction networks were constructed by screening differentially expressed genes and performing gene function enrichment analysis. Results: As a result, five differentially expressed genes were identified: AAMDC, GPR158, RAD9A, STOML1, and STRA13. Immuno-featured differential analysis showed that type 17 T helper cells were more strongly correlated with GPR158 and STRA13, while CD8 T-cell was most strongly correlated with STOML1. Discussion: Therefore, we conclude that the ROP16 protein plays a pivotal role in THP-1 macrophage infection and these five differentially expressed genes may serve as promising molecular targets for the prevention or control of toxoplasmosis. These findings have significant implications for the diagnosis and treatment of toxoplasmosis.
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