ArticleFrontiers in cellular and infection microbiology2024
Corynebacteria from the respiratory microbiota modulate inflammatory responses and associate with a reduced pneumococcal burden in the lungs.
Article in Frontiers in cellular and infection microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Antibacterial and Immunomodulatory Effects ofMicroorganisms · 2026Article
- Association of nasopharyngealMicrobiology spectrum · 2026Article
- Microbial signatures and host immune responses associated with the development of ventilator-associated pneumonia among patients with neurological injuries.Microbiology spectrum · 2026Article
- Dysbiosis of the nasal microbiome is associated with prospective acute exacerbation of COPD.Microbiome · 2026Article
- Interplay of the nasal microbiome and epigenome among adolescents.Clinical epigenetics · 2026Article
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Authors and funding
6 authors.
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Abstract
Background: Certain species from the normal respiratory tract microbiota have recently been proposed to positively influence human health. Method: Respiratory tract epithelial cells NCI-H292 and BALB/cByJ mice were inoculated with Corynebacteria ( Results: Clinical isolates of Corynebacteria were well tolerated by human cells and mice. Corynebacteria induced a transient inflammatory response during healthy conditions in the absence of known pathogens. Pre-exposure or nasal priming with Corynebacteria did not affect subsequent acquisition of pneumococci but were associated with a modulated inflammatory response Conclusions: In this study, we delineate the role of Corynebacteria from the normal microbiota that epidemiologically associate with respiratory health. We show that the presence of Corynebacteria modulates the inflammatory response to pneumococci and associate with faster decrease in pneumococcal burden, primarily in the lower respiratory tract. Our data indicate that Corynebacteria has potential to protect against severe pneumococcal infections.
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