Evidence map›Paper›PMID 39935517›Full record

ArticleClinical and translational imaging2024

Epichaperome-targeted myocardial imaging by

Sonia Mahajan, Milan Grkovski, Kevin D Staton, Susana Ravassa, Kwaku Domfe, H William Strauss, John L Humm, Pat B Zanzonico, Bradley J Beattie, Insang Cho and 8 more

Abstract read
In one paragraph

Article in Clinical and translational imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Sonia MahajanMolecular Imaging & Therapy Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Milan GrkovskiDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Kevin D StatonRadiochemistry & Molecular Imaging Probes Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Susana RavassaProgram of Cardiovascular Diseases, Center for Applied Medical Research Universidad de Navarra, Navarra Institute for Health Research, Carlos III Institute of Health, Pamplona, Navarra, Spain.
Kwaku DomfeState University of New York Upstate Medical University, Syracuse, NY, USA.
H William StraussMolecular Imaging & Therapy Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
John L HummDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Pat B ZanzonicoDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Bradley J BeattieDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Insang ChoMolecular Imaging & Therapy Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Eva M BurnaziRadiochemistry & Molecular Imaging Probes Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Josef J FoxMolecular Imaging & Therapy Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Heiko SchöderMolecular Imaging & Therapy Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Joseph R OsborneDepartment of Radiology, Weill Cornell Medicine, New York, NY, USA.
Trisha YounDepartment of Radiology, Weill Cornell Medicine, New York, NY, USA.
Komal JhaveriDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Gabriela ChiosisProgram in Chemical Biology, Sloan Kettering Institute, New York, NY, USA.
Mark P DunphyMolecular Imaging & Therapy Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Impact of sex differences on the trajectory of interactome dysfunctions across the AD spectrumR01AG074004 · NIA · SLOAN-KETTERING INST CAN RESEARCH · PI CHIOSIS, GABRIELA, GINSBERG, STEPHEN D · 2021 to 2025
$6.0M
Chaperome networks in Alzheimer's diseaseR01AG067598 · NIA · SLOAN-KETTERING INST CAN RESEARCH · PI ARANCIO, OTTAVIO, CHIOSIS, GABRIELA · 2021 to 2025
$5.9M
Selective interactome vulnerability across the Alzheimer’s disease spectrumR01AG072599 · NIA · SLOAN-KETTERING INST CAN RESEARCH · PI GABRIELA CHIOSIS, STEPHEN D GINSBERG · 2023 to 2026
$5.4M
Neuropathology and inflammation in a nonhuman primate model of insulin resistance/metabolic syndromeR01AG085572 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI STEPHEN D GINSBERG, PETER J HAVEL · 2024 to 2026
$3.8M
Small molecule Hsp90 inhibitors in AD treatmentU01AG032969 · NIA · SLOAN-KETTERING INST CAN RESEARCH · PI CHIOSIS, GABRIELA · 2010 to 2014
$3.5M
Biomarkers for predicting response to Hsp90 therapyR01CA172546 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI CHIOSIS, GABRIELA, DUNPHY, MARK P. · 2013 to 2017
$2.9M
A chemical chaperomics platform for ADR56AG061869 · NIA · SLOAN-KETTERING INST CAN RESEARCH · PI CHIOSIS, GABRIELA · 2018 to 2019
$1.8M
Selective interactome vulnerability across the Alzheimer’s disease spectrumR56AG072599 · NIA · SLOAN-KETTERING INST CAN RESEARCH · PI CHIOSIS, GABRIELA, GINSBERG, STEPHEN D · 2021 to 2021
$1.2M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA172546NIA NIH HHS R01 AG067598NIA NIH HHS R01 AG072599NIA NIH HHS R01 AG074004NIA NIH HHS R01 AG085572NIA NIH HHS R56 AG061869NIA NIH HHS R56 AG072599NIA NIH HHS U01 AG032969
6 · The paper itself

Abstract

Background: The small molecule radiotracer Purpose: To describe human Methods: 25 cancer patients (age 22-75 years, M:F - 7:18) with no history of cardiovascular disease received intravenous injections with microdose Results: Myocardial accumulation of Conclusion: Our study finds human myocardial epichaperome expression, as quantified by

Indexed as

Cancer and cardiovascular diseaseIodine-124Myocardial imagingPositron-emission tomographyPU-H71

Identifiers

PMID39935517
PMCPMC11810128

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.