Evidence map›Paper›PMID 39935457›Full record

ArticleiScience2025

Multiple blood feeding bouts in mosquitoes allow for prolonged survival and are predicted to increase viral transmission during dry periods.

Christopher J Holmes, Souvik Chakraborty, Oluwaseun M Ajayi, Melissa R Uhran, Ronja Frigard, Crystal L Stacey, Emily E Susanto, Shyh-Chi Chen, Jason L Rasgon, Matthew DeGennaro and 2 more

Abstract read
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Dehydrating microhabitats increase mite activity and intensify ectoparasitism of Drosophila.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Effect of prolonged dehydration stress on the vector competence ofbioRxiv : the preprint server for biology · 2025
    Article
  9. Review
  10. Revisiting the paradigm of anhematophagy in male mosquitoes.bioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Christopher J HolmesDepartment of Biological Sciences, University of Cincinnati, Cincinnati, OH 45221, USA.
Souvik ChakrabortyDepartment of Biological Sciences, University of Cincinnati, Cincinnati, OH 45221, USA.
Oluwaseun M AjayiDepartment of Biological Sciences, University of Cincinnati, Cincinnati, OH 45221, USA.
Melissa R UhranDepartment of Biological Sciences, University of Cincinnati, Cincinnati, OH 45221, USA.
Ronja FrigardDepartment of Biological Sciences, University of Cincinnati, Cincinnati, OH 45221, USA.
Crystal L StaceyDepartment of Biological Sciences, University of Cincinnati, Cincinnati, OH 45221, USA.
Emily E SusantoDepartment of Biological Sciences, University of Cincinnati, Cincinnati, OH 45221, USA.
Shyh-Chi ChenDepartment of Biological Sciences, University of Cincinnati, Cincinnati, OH 45221, USA.
Jason L RasgonDepartment of Entomology, Center for Infectious Disease Dynamics and Huck Institutes for Life Sciences, Pennsylvania State University, University Park, PA 16802, USA.
Matthew DeGennaroDepartment of Biological Sciences and Biomolecular Sciences Institute, Florida International University, Miami, FL 33199, USA.
Yanyu XiaoDepartment of Mathematical Sciences, University of Cincinnati, Cincinnati, OH 45221, USA.
Joshua B BenoitDepartment of Biological Sciences, University of Cincinnati, Cincinnati, OH 45221, USA.

Funding

Mosquito hydration status as a mechanism that alters pre-feeding host interactions and post-feeding physiologyR01AI148551 · NIAID · UNIVERSITY OF CINCINNATI · PI BENOIT, JOSH B., XIAO, YANYU · 2020 to 2024
$2.1M
tRNA modifications as critical components of insect blood feeding and reproductionR21AI176098 · NIAID · UNIVERSITY OF CINCINNATI · PI BENOIT, JOSH B., LIMBACH, PATRICK A · 2023 to 2024
$446k
Influence of sleep-like states on mosquito behavior and physiologyR21AI166633 · NIAID · UNIVERSITY OF CINCINNATI · PI BENOIT, JOSH B., VINAUGER, CLEMENT · 2022 to 2023
$429k
NIAID NIH HHS R01 AI148551NIAID NIH HHS R21 AI166633NIAID NIH HHS R21 AI176098
6 · The paper itself

Abstract

Dry conditions increase blood feeding in mosquitoes, but it is unknown if dehydration-induced bloodmeals are increased beyond what is necessary for reproduction. In this study, we investigated the role of dehydration in secondary blood feeding behaviors of mosquitoes. Following an initial bloodmeal, prolonged exposure to dry conditions increased secondary blood feeding in mosquitoes by nearly two-fold, and chronic blood feeding allowed mosquitoes to survive up to 20 days without access to water. Exposure to desiccating conditions following a bloodmeal resulted in increased activity, decreased sleep levels, and prompted a return of CO

Indexed as

EntomologyEnvironmental healthVirology

Identifiers

PMID39935457
PMCPMC11810705

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.