Evidence map›Paper›PMID 39935454›Full record

ArticleiScience2025

Female mice lacking GluA3 show early onset of hearing loss, cochlear synaptopathy, and afferent terminal swellings in ambient sound levels.

Indra Pal, Atri Bhattacharyya, Babak V-Ghaffari, Essence Devine Williams, Maolei Xiao, Mark Allen Rutherford, María Eulalia Rubio

Abstract read
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Indra PalDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Atri BhattacharyyaDepartment of Otolaryngology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Babak V-GhaffariDepartment of Otolaryngology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Essence Devine WilliamsDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Maolei XiaoDepartment of Otolaryngology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Mark Allen RutherfordDepartment of Otolaryngology, Washington University School of Medicine, St. Louis, MO 63110, USA.
María Eulalia RubioDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

Funding

Mechanisms of hypersensitivity to sound-induced cochlear damageR01DC013048 · NIDCD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Maria-Eulalia Rubio-Valero · 2013 to 2026
$6.8M
EXCITATION AND EXCITOTOXICITY IN TYPE I COCHLEAR AFFERENTS: SYNAPTIC STRUCTURE AND FUNCTIONR01DC014712 · NIDCD · WASHINGTON UNIVERSITY · PI Mark Allen Rutherford · 2016 to 2026
$5.6M
Mechanisms of hypersensitivity to sound-induced cochlear damageR56DC013048 · NIDCD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RUBIO-VALERO, MARIA-EULALIA · 2018 to 2018
$304k
NIDCD NIH HHS R01 DC013048NIDCD NIH HHS R01 DC014712NIDCD NIH HHS R56 DC013048
6 · The paper itself

Abstract

AMPA-type glutamate receptors (AMPARs) mediate excitatory cochlear transmission. However, unique roles of AMPAR subunits are unresolved. Lack of subunit GluA3 (

Indexed as

Cellular neuroscienceNeuroscienceSensory neuroscience

Identifiers

PMID39935454
PMCPMC11810710

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.