Evidence map›Paper›PMID 39935268›Full record

ArticleMedical physics2025

Automatic bone marrow segmentation for precise [

Zhonglin Lu, Jiaxi Hu, Gefei Chen, Han Jiang, Cheng-Ting Shih, Ali Afshar-Oromieh, Axel Rominger, Kuangyu Shi, Greta S P Mok

Abstract read
In one paragraph

Article in Medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Inter-center variability of dosimetry methodology and the impact on reported absorbed dose for [European journal of nuclear medicine and molecular imaging · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. AI in SPECT Imaging: Opportunities and Challenges.Seminars in nuclear medicine · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhonglin LuBiomedical Imaging Laboratory (BIG), Department of Electrical and Computer Engineering, Faculty of Science and Technology, University of Macau, Taipa, Macau SAR, China.
Jiaxi HuDepartment of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Gefei ChenBiomedical Imaging Laboratory (BIG), Department of Electrical and Computer Engineering, Faculty of Science and Technology, University of Macau, Taipa, Macau SAR, China.
Han JiangBiomedical Imaging Laboratory (BIG), Department of Electrical and Computer Engineering, Faculty of Science and Technology, University of Macau, Taipa, Macau SAR, China.
Cheng-Ting ShihDepartment of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan.
Ali Afshar-OromiehDepartment of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Axel RomingerDepartment of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Kuangyu ShiDepartment of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Greta S P MokBiomedical Imaging Laboratory (BIG), Department of Electrical and Computer Engineering, Faculty of Science and Technology, University of Macau, Taipa, Macau SAR, China.

Funding

University of MacauUniversity of Macau Development Foundation MYRG-GRG2024-00061-FST-UMDF
6 · The paper itself

Abstract

backgroundBone marrow (BM) is the dominant dose-limiting organ in [ PURPOSE: We aim to develop an automatic image-based segmentation method on peri-therapeutic sequential [

methodsQuantitative SPECT/CT imaging at 2, 20, 40 and 60 (n = 14)/200 (n = 16) h post [

resultsIn 30 cycles of 10 patients, the average Dice is 0.76 ± 0.18 for the X-means clustering method, as compared to 0.61 ± 0.19 for the single threshold method. The gold standard yields mean BM D

conclusionsX-means clustering is feasible to segment the BM based on the CT images of peri-therapy SPECT/CT and shows advantages compared with the single threshold and empirical sphere segmentation methods.

Indexed as

Bone MarrowDipeptidesHeterocyclic Compounds, 1-RingImage Processing, Computer-AssistedLutetiumAutomationHumansMaleRadioisotopesRadiometrySingle Photon Emission Computed Tomography Computed TomographyDipeptidesHeterocyclic Compounds, 1-RingLutetiumLutetium-177Radioisotopes[177Lu]Lu‐PSMA‐617bone marrowdosimetrysegmentationSPECT/CT

Identifiers

PMID39935268
PMCPMC12149722

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.