ArticleEuropean heart journal. Cardiovascular Imaging2025
Incremental value of multiparametric cardiac magnetic resonance imaging for non-invasive identification of significant acute cardiac allograft rejection: a prospective and biopsy-proven study.
Article in European heart journal. Cardiovascular Imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Article
- Role of Cardiovascular Magnetic Resonance in Post-Heart Transplant Surveillance: Integrating Evidence with Prospective Cohort Data.Journal of personalized medicine · 2026Article
- The use of multimodality imaging in heart transplant recipients: a case series.European heart journal. Case reports · 2025Article
- Left ventricular longitudinal function is reduced but partially compensated by increased radial function after heart transplantation.JHLT open · 2025Article
- Full free-breathing cardiovascular magnetic resonance imaging: enhancing efficiency and image quality in clinical practice.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025Article
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Authors and funding
15 authors.
Funding
Abstract
aimsThis study aimed to evaluate the association between cardiac magnetic resonance imaging (CMR) multiparameters and significant acute cardiac allograft rejection (SR), and assess the incremental value of CMR multiparameters over conventional serum examinations for identifying SR. METHODS AND
resultsHeart transplantation (HTx) recipients with endomyocardial biopsy and healthy controls were prospectively recruited for CMR assessment. CMR feature tracking was performed to evaluate the left ventricular (LV) global strain in all three directions. The last serum examinations including N-terminal pro-brain natriuretic peptide (NT-proBNP) before anti-rejection therapy were recorded. Participants were divided into three groups: control, SR [acute cellular rejection grade ≥ 2R and/or antibody-mediated rejection (AMR) grade ≥ pAMR1], and NSR (non-SR). Finally, 30 controls (43.3 ± 13.6 years, 26 males) and 51 HTx recipients comprising 23 SRs (48.6 ± 12.6 years, 24 males) and 28 NSRs (42.7 ± 14.9 years, 16 males) were enrolled for analysis. Compared with NSRs, SRs showed elevated NT-proBNP (7797.0 ± 7527.6 pg/mL vs. 3334.6 ± 5935.3 pg/mL, P < 0.001), worse LV global longitudinal strain (GLS) (-9.7 ± 3.1% vs. -13.1 ± 2.9%, P < 0.001), and increased native T1 (1384 ± 80.1 ms vs. 1321 ± 69.9 ms, P < 0.001) and T2 values (50.9 ± 2.7 ms vs. 45.7 ± 4.3 ms, P < 0.001). In multivariable analysis, LVGLS (OR = 0.76, 95% CI, 0.59-0.98, P = 0.03) and T2 value (OR = 1.35, 95% CI, 1.10-1.65, P = 0.01) were independently associated with SR after NT-proBNP adjustment. Furthermore, the likelihood ratio test showed LVGLS (P = 0.002) and T2 value (P < 0.001) had incremental value over NT-proBNP for identifying SR.
conclusionLVGLS and T2 value were independently associated with SR, providing incremental value for non-invasive identification of significant rejection in HTx recipients.
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