ArticleBrain and behavior2025
Somatosensory-Thalamic Functional Dysconnectivity Associated With Poststroke Motor Function Rehabilitation: A Resting-State fMRI Study.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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10 authors.
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Abstract
backgroundThe thalamus plays a pivotal role in functional brain networks, yet its contribution to motor function recovery following stroke remains elusive. We aim to explore changes in thalamocortical functional connectivity poststroke and its correlation with motor function.
methodsThirty-nine subacute ischemic stroke patients and 32 healthy individuals underwent resting-state functional magnetic resonance imaging (MRI). The Fugl-Meyer Assessment (FMA) was employed to evaluate upper and lower extremity motor function before and 1 year after stroke rehabilitation. The ipsilesional thalamus and contralesional thalamus were parceled into functional regions of interest (ROIs) based on connectivity with six cortical ROIs: prefrontal, motor, temporal, posterior parietal, somatosensory, and occipital cortex. Functional connectivity between each cortical ROI and its corresponding thalamic ROI was calculated and compared between groups. Differences identified in the ROI-to-ROI analysis were further investigated through seed-to-voxel whole-brain connectivity analyses to pinpoint thalamic dysconnectivity. Correlations with upper and lower extremity motor function were also analyzed.
resultsSignificant changes in thalamocortical functional connectivity were observed after stroke in ROI-to-ROI analysis, with bilateral somatosensory-thalamic connectivity decreased and ipsilesional temporal-thalamic and bilateral occipital-thalamic connectivity increased. Seed-to-voxel analysis localized ipsilesional thalamic hypoconnectivity to the ipsilesional rolandic operculum and ipsilesional precentral gyrus. Ipsilesional somatosensory-thalamic connectivity was positively correlated with baseline upper extremity FMA scores and negatively correlated with upper extremity motor function change rate at 1-year postdischarge.
conclusionsThis study provides new insights into the role of the thalamus in motor function recovery after stroke, offering preliminary evidence for its potential as a therapeutic target in poststroke rehabilitation.
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