Evidence map›Paper›PMID 39934881›Full record

GuidelineAdvances in rheumatology (London, England)2025

Recommendations on neurologic, cognitive, and psychiatric manifestations in patients with Sjögren's disease by the Brazilian Society of Rheumatology.

Fabiola Reis de Oliveira, Simone Appenzeller, Sandra Gofinet Pasoto, Marilena Leal Mesquita Silvestre Fernandes, Maria Lucia Lemos Lopes, Sonia Cristina de Magalhães Souza Fialho, Aysa Cesar Pinheiro, Laura Caldas Dos Santos, Valeria Valim, Erica Vieira Serrano and 13 more

Abstract readSystematic ReviewPractice Guideline
In one paragraph

Guideline in Advances in rheumatology (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Fabiola Reis de OliveiraHospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (HCFMRP-USP), Av. Bandeirantes 3900, Vila Monte Alegre, Ribeirão Preto, SP, CEP: 14049-900, Brazil.ORCID 0000-0002-9196-7422
Simone AppenzellerDepartamento de Ortopedia, Reumatologia e Traumatologia, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, R. Tessália Vieira de Camargo, 126 - Cidade Universitária, Campinas, SP, CEP: 13083-887, Brazil. appenzellersimone@gmail.com.ORCID 0000-0001-5075-4474
Sandra Gofinet PasotoDisciplina de Reumatologia, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, R. Dr. Ovídio Pires de Campos, 225 - Cerqueira César, São Paulo, SP, CEP: 05403-010, Brazil.ORCID 0000-0002-7343-6804
Marilena Leal Mesquita Silvestre FernandesDisciplina de Reumatologia, Hospital Federal dos Servidores do Estado do Rio de Janeiro, R. Sacadura Cabral, 178, Saúde, Rio de Janeiro, RJ, CEP: 20221-903, Brazil.ORCID 0009-0000-3283-6548
Maria Lucia Lemos LopesDisciplina de Reumatologia, Departamento de Clínica Médica, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), R. Sarmento Leite, 245 - Centro Histórico de Porto Alegre, Porto Alegre, RS, CEP: 90050-170, Brazil.ORCID 0000-0002-6971-5667
Sonia Cristina de Magalhães Souza FialhoDisciplina de Reumatologia, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, R. Dr. Ovídio Pires de Campos, 225 - Cerqueira César, São Paulo, SP, CEP: 05403-010, Brazil.ORCID 0000-0001-8771-1355
Aysa Cesar PinheiroDepartamento de Reumatologia, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, 1235, Cidade Universitária, Recife, PE, CEP: 50670-901, Brazil.ORCID 0000-0001-5075-8926
Laura Caldas Dos SantosDepartamento de Oftalmologia, Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM-UNIFESP), Rua Botucatu, 820, Vila Clementino, São Paulo, SP, CEP: 04023-062, Brazil.ORCID 0000-0001-5332-4947
Valeria ValimDepartamento de Clínica Médica, Serviço de Reumatologia, Universidade Federal do Espírito Santo, Pós Graduação em Saúde Coletiva, Hospital Universitário Cassiano Antônio de Moraes, Av. Marechal Campos, 1468, Maruípe, Vitória, ES, CEP: 29075-910, Brazil.ORCID 0000-0002-0625-1308
Erica Vieira SerranoHospital Universitário Cassiano Antônio de Moraes, Vitória, Brazil.ORCID 0000-0002-7243-7434
Sandra Lucia Euzébio RibeiroDisciplina de Reumatologia, Faculdade de Medicina, Universidade Federal do Amazonas, Rua Afonso Pena, 1053, Manaus, AM, CEP: 69020-160, Brazil.ORCID 0000-0002-4777-8659
Tatiana Nayara Libório-KimuraDisciplina de Reumatologia, Faculdade de Medicina, Universidade Federal do Amazonas, Rua Afonso Pena, 1053, Manaus, AM, CEP: 69020-160, Brazil.ORCID 0000-0001-7800-8326
Danielle Christinne Soares do EgyptoDisciplina de Reumatologia, Departamento de Medicina Interna, Centro de Ciências Médicas, Universidade Federal da Paraíba (UFPB), Campus I - Lot. Cidade Universitária, Paraíba, PB, CEP: 58051-900, Brazil.ORCID 0000-0002-8236-024X
Diego Ustárroz CantaliServiço de Reumatologia, Hospital São Lucas da Pontifícia Universidade Católica do Rio Grande de Sul (PUCRS), Av. Ipiranga, 6690 ‑ Jardim Botânico, Porto Alegre, RS, CEP: 90610‑000, Brazil.ORCID 0000-0001-8103-0532
Juliana D'Agostino GennariServiço de Reumatologia da Santa Casa de São Paulo, R. Dr. Cesário Mota Júnior, 112, Vila Buarque, São Paulo, SP, CEP: 01221-020, Brazil.ORCID 0000-0003-3267-3106
Samira Tatiyama MiyamotoDepartamento de Educação Integrada em Saúde, Universidade Federal do Espírito Santo, Av. Marechal Campos, 1468, Maruípe, Vitória, ES, CEP: 29040-090, Brazil.ORCID 0000-0003-0609-4063
Karina Gatz CapobiancoHospital Moinhos de Vento, R. Ramiro Barcelos, 910, Bairro Floresta, Porto Alegre, RS, Brazil.ORCID 0009-0004-9851-4049
Alisson Aliel Vigano PugliesiDepartamento de Ortopedia, Reumatologia e Traumatologia, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, R. Tessália Vieira de Camargo, 126 - Cidade Universitária, Campinas, SP, CEP: 13083-887, Brazil.ORCID 0000-0003-0444-738X
Vinicius Tassoni CivileDisciplina de Medicina de Urgência e Medicina Baseada em Evidências, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Botucatu, 740, Vila Clementino, São Paulo, SP, CEP: 04023-062, Brazil.ORCID 0000-0002-1718-6281
Ana Carolina Pereira Nunes PintoDisciplina de Medicina de Urgência e Medicina Baseada em Evidências, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Botucatu, 740, Vila Clementino, São Paulo, SP, CEP: 04023-062, Brazil.ORCID 0000-0002-1505-877X
César Ramos Rocha-FilhoDisciplina de Medicina de Urgência e Medicina Baseada em Evidências, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Botucatu, 740, Vila Clementino, São Paulo, SP, CEP: 04023-062, Brazil.ORCID 0000-0002-7190-0263
Aline Pereira da RochaDisciplina de Medicina de Urgência e Medicina Baseada em Evidências, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Botucatu, 740, Vila Clementino, São Paulo, SP, CEP: 04023-062, Brazil.ORCID 0000-0002-0863-6500
Virginia Fernandes Moça TrevisaniDisciplina de Medicina de Urgência e Medicina Baseada em Evidências, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Botucatu, 740, Vila Clementino, São Paulo, SP, CEP: 04023-062, Brazil.ORCID 0000-0002-7180-6285

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 303116/2022-6Conselho Nacional de Desenvolvimento Científico e Tecnológico 305981/2023-4
6 · The paper itself

Abstract

backgroundNeurological and psychiatric manifestations occur in patients with primary Sjogren's disease (SjD) with a wide-ranging clinical presentation, affecting quality of life, social participation, and prognosis. Despite this, neither central nor peripheral neurological symptoms are systematically evaluated in the context of autoimmunity or identified as manifestations of SjD. The EULAR Sjogren's Syndrome Disease Activity Index (ESSDAI) covers only part of them in the neurological domain.

methodsWe performed a systematic review of the diagnosis and prevalence of central, peripheral, and autonomic nervous system manifestations in primary SjD, following the recommendations proposed by the Cochrane Collaboration Handbook. Observational studies were included when their main issue was the diagnosis and the prevalence of the manifestations individually. We employed a generalized linear mixed model (GLMM) method with a random-effects model, and the results were computed using logit transformation, implemented through the 'meta' and 'metafor' packages in the R software (version 3.6.1). To present these recommendations, agreement among experts was investigated using the Delphi method in in-person meetings.

resultsWe propose ten recommendations regarding the investigation and management of neurological involvement in SjD that had 100% agreement among participants.

conclusionThese recommendations add to the literature on the clinical care of patients with SjD.

Indexed as

Mental DisordersNervous System DiseasesSjogren's SyndromeBrazilDelphi TechniqueHumansQuality of LifeRheumatologySocieties, MedicalCentral nervous systemCognitive impairmentsNeurological manifestationsPeripheral nervous systemPsychiatric diseaseSjögren’s disease.Sjögren’s syndrome

Identifiers

PMID39934881
PMCPMC13488763

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.