ArticleImmunity & ageing : I & A2025
The relationship between biological aging and psoriasis: evidence from three observational studies.
Article in Immunity & ageing : I & A, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Epigenetic Age Acceleration as a Modifiable Public Health Target: A Systematic Review and Meta-Analysis of Environmental, Behavioral, and Social Determinants with Development of the MEAB-Index.International journal of molecular sciences · 2026Pooled it
- Superficial Fungal Infection Associations with Comorbid Diseases and Risk Factors: An Analysis of Global Burden of Disease 2023.Infectious disease reports · 2026Article
- Deep Biological Clocks in Critical Care Medicine: A Scoping Review Toward Translational Precision Care.Journal of personalized medicine · 2026Review
- Aging-associated immune and stromal programs mark interferon- and remodeling-linked spatial contexts in psoriatic skin.Frontiers in immunology · 2026Article
- Social Determinants of Health as a Predictor of Psoriasis Risk: Preliminary Findings from a National Survey.Clinical, cosmetic and investigational dermatology · 2026Article
- Inflammaging and Senescence-Associated Secretory Phenotype (SASP) in Psoriasis - A Narrative Review of Potential Mechanisms and Anti-Inflammaging Strategies.Psoriasis (Auckland, N.Z.) · 2026Review
- Mediating role of aging and obesity in the relationship between dietary index for gut microbiota and metabolic syndrome and its potential regulatory mechanisms.European journal of medical research · 2025Article
- Psoriasis and phenotypic age acceleration in relation to all-cause and cardiovascular disease mortality risks in US adults.European journal of medical research · 2025Article
- Review
- Exploring the association between relative fat mass and psoriasis risk: insights from the NHANES data.Lipids in health and disease · 2025Article
- Accelerated biological aging as a potential mediator mediates the relationship between metabolic syndrome and the risk of psoriasis: a prospective analysis from the UK biobank.Frontiers in immunology · 2025Article
- The Association Between Accelerated Biological Aging as Measured by KDMAge and PhenoAge and Digestive System Cancer Risk: A Cross-Sectional Study Using NHANES Data (1999-2018).Journal of digestive diseasesArticle
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Authors and funding
10 authors.
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Abstract
backgroundThe relationship between psoriasis and aging remains unclear. Biological age is considered as a tool for strong association with aging, but there is a lack of reports on the relationship between biological age and psoriasis. Therefore, this study aimed to explore the relationship between biological age and psoriasis.
methodsPatients with psoriasis and non-psoriasis were recruited from National Health and Nutrition Examination Survey (NHANES) (12,973 cases), Medical Information Mart for Intensive Care (MIMIC-IV) (558 cases) and The First Clinical Medical College of Zhejiang Chinese Medical University (206 cases). Biological age was calculated using Klemera-Doubal method age (KDM-age) and phenotypic age (PhenoAge). Linear regression and logistic regression were used to explore the association between psoriasis and biological age advance. Cox regression was used to investigate the association between biological age advance and mortality. Finally, biological age advance was used to predict the death of psoriasis patients.
resultsIn NHANES, linear regression showed that psoriasis led to a 0.54 advance in PhenoAge (Adjust Beta: 0.54, 95CI: 0.12-0.97, p = 0.018). The KDM-age advance due to psoriasis was not statistically significant (p = 0.754). Using data from China, we came to the new conclusion that for every unit rise in Psoriasis Area and Severity Index, PhenoAge advance rose by 0.12 (Beta: 0.12, 95CI: 0.01-0.22, p = 0.031). Using NHANES data, cox regression shows for every unit rise in PhenoAge advance patients had an 8% rise in mortality (Adjust hazard ratio: 1.08, 95CI: 1.04-1.12, p < 0.001). Using MIMIC-IV, logistic regression showed a 13% increase in mortality within 28 days of admission for every 1 unit rise in PhenoAge advance (odds ratio: 1.13, 95CI: 1.09-1.18, P < 0.001). Finally, we used PhenoAge advance to predict death, with an AUC of 0.71 in the NHANES, an ACU of 0.79 for predicting death within 1 years in the general ward of MIMIC-IV. In the ICU of MIMIC-IV, the AUC for predicting death within 28 days was 0.71.
conclusionPsoriasis leads to accelerated biological aging in patients, which is associated with the severity of psoriasis and more comorbidities. In addition, PhenoAge has the potential to monitor the health status of patients with psoriasis.
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