Naringenin-loaded nanoparticles modulate HIF-driven oxygen-sensing pathways in lung adenocarcinoma cells.

Eman M Ragab, Doaa M El Gamal, Tarek M Mohamed, Abeer A Khamis

Abstract read

In one paragraph

Article in BMC research notes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Eman M RagabBiochemistry Division, Chemistry Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt. eman_mousa@science.tanta.edu.eg.ORCID http://orcid.org/0000-0001-7425-1388

Doaa M El GamalBiochemistry Division, Chemistry Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt.

Tarek M MohamedBiochemistry Division, Chemistry Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt.

Abeer A KhamisBiochemistry Division, Chemistry Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHypoxia is a common symptom of lung cancer. Proliferation and neovascularization mediated by hypoxia-inducible factors (HIF) influence several adaptations. It has recently been established that naringenin (NAR) and its nanoparticles are chemo-preventive flavonoids in lung cancer.

aimAdjust HIF activity by reviving oxygen-sensing enzyme activity while considering possible therapeutic targets.

methodThe bindings of NAR to target proteins were examined using computational modeling techniques. Additionally, NAR nanoparticles (NARNPs) were synthesized and characterized. Normal fibroblast cells and A549 cells were used to determine cytotoxicity. Colorimetric analysis of α-ketoglutarate detection for hydroxylases.

resultsAccording to molecular modeling, NAR and target proteins have a high affinity. The PHD and FIH activities in A549 are significantly stimulated.

conclusionNAR and NARNPs diminish hypoxia in lung cancer by stimulating oxygen-sensing hydroxylases.

Indexed as

Adenocarcinoma of LungFlavanonesLung NeoplasmsNanoparticlesOxygenA549 CellsHumansMixed Function OxygenasesFlavanonesMixed Function OxygenasesnaringeninOxygenChitosanHypoxiaHypoxia-inducible factorLung cancerNaringenin

Identifiers

PMID39934840

DOI10.1186/s13104-025-07133-2

PMCPMC11817823

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.