Evidence map›Paper›PMID 39934750›Full record

ArticleBMC cancer2025

Body mass index and risk of connective and soft tissue cancer: results from a large cohort of 1.7 million individuals in Norway.

Dagfinn Aune, Marie Nordsletten, Tor Åge Myklebust, Trude Eid Robsahm, Bjørn Steen Skålhegg, Tom Mala, Sheraz Yaqub, Usman Saeed

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Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Dagfinn AuneDepartment of Research, Cancer Registry of Norway, Norwegian Institute of Public Health, Oslo, Norway. d.aune@imperial.ac.uk.
Marie NordslettenDepartment of Gastrointestinal and Paediatric Surgery, Oslo University Hospital, Oslo, Norway.
Tor Åge MyklebustDepartment of Research, Cancer Registry of Norway, Norwegian Institute of Public Health, Oslo, Norway.
Trude Eid RobsahmDepartment of Research, Cancer Registry of Norway, Norwegian Institute of Public Health, Oslo, Norway.
Bjørn Steen SkålheggDivision for Molecular Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Tom MalaDepartment of Gastrointestinal and Paediatric Surgery, Oslo University Hospital, Oslo, Norway.
Sheraz YaqubDepartment of Gastrointestinal and Paediatric Surgery, Oslo University Hospital, Oslo, Norway.
Usman SaeedDepartment of Gastrointestinal and Paediatric Surgery, Oslo University Hospital, Oslo, Norway.

Funding

World Cancer Research Fund International IIG_FULL_2020_035
6 · The paper itself

Abstract

backgroundFew studies have investigated the association between adiposity and connective and soft tissue cancer, a rare and understudied cancer entity. We investigated this association in a large cohort of more than 1.7 million individuals in Norway.

methodsThe study cohort included 1,723,692 men and women aged 16-75 years at baseline in 1963-1975. Data on weight and height measurements from the Norwegian Tuberculosis Screening Programme were linked to the Cancer Registry. We estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations between body mass index (BMI) and risk of connective and soft tissue cancer, adjusting for age and sex.

resultsIn total 1758 connective and soft tissue cancer cases were registered during 56.1 million person-years of follow-up. The HRs (95% CIs) for the BMI categories of 15-<18.5, 18.5-<25.0 (reference), 25.0-<30.0, 30.0-<35.0, ≥ 35.0 were 0.77 (0.50-1.20), 1.00 (reference), 1.15 (1.03-1.27), 1.28 (1.06-1.54), and 1.69 (1.21-2.37, p

conclusionThese results suggest that higher BMI overall and in early adulthood may be associated with increased risk of connective and soft tissue cancer, but BMI seems not to influence early-onset disease. Large cohort studies with more detailed information on confounding factors and BMI trajectories over time are needed for further verification before firm conclusions can be made.

Indexed as

Body Mass IndexObesitySoft Tissue NeoplasmsAdolescentAdultAgedCohort StudiesFemaleHumansMaleMiddle AgedNorwayRegistriesRisk FactorsYoung AdultBody mass indexCohort studyConnective and soft tissue cancerObesity

Identifiers

PMID39934750
PMCPMC11817836

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