Evidence map›Paper›PMID 39934737›Full record

Trial reportBMC psychiatry2025

Comparative effectiveness of short-term psychodynamic psychotherapy and cognitive behavioral therapy for major depression in psychiatric outpatient clinics: a randomized controlled trial.

Anders Malkomsen, Theresa Wilberg, Bente Bull-Hansen, Toril Dammen, Julie Horgen Evensen, Benjamin Hummelen, André Løvgren, Kåre Osnes, Randi Ulberg, Jan Ivar Røssberg

Registry-linked trialAbstract readRandomized Controlled TrialComparative Study
In one paragraph

Trial report in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03022071 (What Works for Whom and How? Mechanisms of Change in Psychotherapy), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03022071 nacompletednot on this map

What Works for Whom and How? Mechanisms of Change in Psychotherapy

TypeinterventionalSponsorOslo University HospitalRan2017 to 2023Enrolled100ConditionsDepressionArmsCognitive behavior therapy
3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Article
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  5. Unilateral prosopometamorphopsia caused by infarction of the splenium of the corpus callosum: 4 case report and review of the literature.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anders MalkomsenDivision of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway. anmalk@ous-hf.no.
Theresa WilbergDivision of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Bente Bull-HansenDiakonhjemmet Hospital, Division of Mental Health and Substance Abuse, Oslo, Norway.
Toril DammenDivision of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Julie Horgen EvensenDivision of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Benjamin HummelenDivision of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
André LøvgrenDivision of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Kåre OsnesDiakonhjemmet Hospital, Division of Mental Health and Substance Abuse, Oslo, Norway.
Randi UlbergInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Jan Ivar RøssbergDivision of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMore studies with low risk of bias on the effectiveness of cognitive behavioral therapy (CBT) and short-term psychodynamic psychotherapy (STPP) for major depressive disorder (MDD) are needed. This study compares the outcome of CBT and STPP and examines the improvements in each treatment, focusing on effect sizes, reliable change, dropout rates, and remission rates, using broad inclusion criteria (e.g. participants using antidepressants or with strong suicidal ideation).

methodsOne hundred patients were randomly allocated to CBT or STPP. All patients were offered either 16 weekly sessions followed by 3 monthly booster sessions in CBT, or 28 weekly sessions in STPP. Primary outcome measures were Hamilton Depression Rating Scale (HDRS) and Beck's Depression Inventory-II (BDI-II). Secondary outcome measures were Work and Social Adjustment Scale (WSAS), Generalized Anxiety Disorder-7 (GAD-7), Global Assessment of Functioning (GAF) and Short Form Health Survey-12 (SF-12).

resultsNo significant differences in outcomes were found between the two treatment groups on any of the measures. The within-group effects were large (> 0.8) for the primary outcome measures and moderate to large for the secondary outcome measures. According to the reliable change index (RCI), 79% of patients reliably improved on HDRS and 76% improved on BDI-II, whereas respectively 6% and 10% reliably deteriorated.

conclusionsThese findings support the assumption that CBT and STPP are equally effective treatments for patients with depressive disorders in psychiatric outpatient clinics. Additionally, they strengthen the evidence for the effectiveness of both CBT and STPP in these settings, while also highlighting that not all depressed patients respond to short-term treatment. CLINICAL

trial registrationClinical Trial gov. Identifier: NCT03022071. Date of registration: 2016-11-14.

Indexed as

Cognitive Behavioral TherapyMajor Depressive DisorderPsychotherapy, BriefPsychotherapy, PsychodynamicAdultAmbulatory Care FacilitiesFemaleHumansMaleMiddle AgedPsychiatric Status Rating ScalesTreatment OutcomeCognitive behavioral therapyDepressionEffectivenessOutpatient clinicPsychoanalyticShort-term psychodynamic psychotherapy

Identifiers

PMID39934737
PMCPMC11817821

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.