SynthesisBMC infectious diseases2025
Tissue infarction secondary to brucellosis: a systematic review of case reports and case series.
Synthesis in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Frequency of Human Brucellosis Complications in West Asia: A Systematic Review and Meta-Analysis.MicrobiologyOpen · 2026Pooled it
- [Research progress on brucellosis combined with liver injury].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTissue infarction is a rare but serious life-threatening complication of brucellosis. In this systematic review, we investigated manifestations, diagnostic and therapeutic measures, and causes of tissue infarction in patients with brucellosis.
methodsPubmed/Medline, Embase, Scopus, and Web of Science were systematically searched for case reports or case series that detail tissue infarction secondary to brucellosis up to October 20, 2024. Baseline characteristics, clinical and paraclinical findings, infarcted tissue details, treatments, and outcomes of the patients were independently extracted by two reviewers.
resultsA total of 34 articles were included, reporting on 36 brucellosis patients with tissue infarction in the central nervous system (CNS) (n = 24), spleen (n = 6), heart (n = 3), kidney (n = 1), bowel (n = 1), and three organs-spleen-bowel-kidney- (n = 1). These patients primarily presented with flu-like symptoms and organ-specific manifestations resulting from tissue infarction. Laboratory findings were predominantly suggestive of brucellosis. Furthermore, tissue infarctions were confirmed by imaging in all cases. Most patients indicated improvement with medications and surgical interventions.
conclusionTissue infarction in patients with brucellosis can impact various organs, particularly the brain, spleen, and heart, with symptoms differing based on the specific organ involved. As patients with brucellosis exhibit symptoms of tissue infarction, healthcare providers should be aware of this complication. Prompt diagnosis can be achieved through laboratory and imaging investigations. Appropriate medical and surgical treatments should be provided for these cases.
trial registrationThe study protocol was registered in the international prospective registry of systematic reviews known as PROSPERO (Protocol number: CRD42024595263).
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