Evidence map›Paper›PMID 39934644›Full record

ArticlePediatric research2025

Global burden of multidrug-resistant tuberculosis in children and adolescents.

Yanyan Zhong, Huiru Xie, Fucheng Cai, Miao Liu, Hui Gan, Zhuo Tang, Yan Bai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yanyan ZhongDepartment of Pediatrics, Huazhong University of Science and Technology Hospital, Wuhan, China.
Huiru XieDepartment of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Fucheng CaiDepartment of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Miao LiuDepartment of Pediatrics, Renmin Hospital of Wuhan University, Wuhan, China.
Hui GanDepartment of Allergy and Clinical Immunology, Department of Laboratory, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.
Zhuo TangDepartment of Pediatrics, Huazhong University of Science and Technology Hospital, Wuhan, China.
Yan BaiDepartment of Pediatrics, Shenzhen Third People's Hospital, Shenzhen, Guangdong Province, China. yanbaixh@hust.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesMultidrug-resistant tuberculosis (MDR-TB) has become a major global public health issue, which has worsened over time owing to changes in disease-related trends. This study aimed to determine global trends in MDR-TB among children and adolescents for strategic health planning.

methodsA secondary analysis was performed on MDR-TB burden among children and adolescents (<20 years) at the global, regional, and national levels based on sociodemographic index (SDI) quintiles from 1990 to 2019, using the Global Burden of Disease (GBD) 2019 database.

resultsIn 2019, 67,710.82 (95% uncertainty interval [UI]: 38,823.61 to 110,582.03) incidents of MDR-TB were reported among children and adolescents aged <20 years worldwide. The global incidence rate has increased from 1990 to 2019, with the estimated annual percentage change (EAPC) at 4.15% (95% UI: 1.10-12.19%), particularly in low- and low-middle SDI regions. The top three highest incidence rates were observed in Southern sub-Saharan Africa, Eastern Europe, and South Asia. The mortality and disability-adjusted life years (DALYs) rates (0.62 [95% UI: 0.28-1.14] and 55.19 [95% UI: 25.24-100.74] cases per 100,000, respectively) were higher among children aged <5 years than those in older age groups in 2019.

conclusionThe global burden of MDR-TB among children and adolescents has increased from 1990 to 2019, particularly in regions with lower SDI. Extensive collaborative research and interventions are needed to mitigate this disease burden to secure the health of our future generation. IMPACT: MDR-TB disease burden in children and adolescents using GBD 2019 database was analyzed. In total, 67710.82 MDR-TB cases were identified in children and adolescents in 2019. Global MDR-TB burden in children and adolescents has risen over the past 30 years. MDR-TB disease burden is negatively correlated with the sociodemographic index. MDR-TB disease burden varies across countries and age groups.

Indexed as

Adolescent HealthChild HealthGlobal Burden of DiseaseGlobal HealthTuberculosis, Multidrug-ResistantAdolescentChildChild, PreschoolDisability-Adjusted Life YearsFemaleHumansIncidenceInfantInfant, NewbornMaleSecondary Data Analysis

Identifiers

PMID39934644
PMCPMC12507668

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.