Evidence map›Paper›PMID 39934590›Full record

Observational studyClinical and experimental nephrology2025

Relationship between new-onset proteinuria and the volume of the non-donated kidney before and after donation in living kidney donors.

Masatomo Ogata, Takamasa Miyauchi, Kiyomi Osako, Naohiko Imai, Yuko Sakurai, Kazunobu Shinoda, Yugo Shibagaki, Masahiko Yazawa

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Clinical and experimental nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Masatomo OgataDivision of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1, Sugao, Miyamae-Ku, Kawasaki, Kanagawa, 216-8511, Japan.
Takamasa MiyauchiDivision of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1, Sugao, Miyamae-Ku, Kawasaki, Kanagawa, 216-8511, Japan.
Kiyomi OsakoDivision of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1, Sugao, Miyamae-Ku, Kawasaki, Kanagawa, 216-8511, Japan.
Naohiko ImaiDivision of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1, Sugao, Miyamae-Ku, Kawasaki, Kanagawa, 216-8511, Japan.
Yuko SakuraiDepartment of Pharmacy, St Marianna University School of Medicine, 2-16-1, Sugao, Miyamae-Ku, Kawasaki, Kanagawa, Japan.
Kazunobu ShinodaDepartment of Urology, St Marianna University School of Medicine, 2-16-1, Sugao, Miyamae-Ku, Kawasaki, Kanagawa, Japan.
Yugo ShibagakiDivision of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1, Sugao, Miyamae-Ku, Kawasaki, Kanagawa, 216-8511, Japan.
Masahiko YazawaDivision of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1, Sugao, Miyamae-Ku, Kawasaki, Kanagawa, 216-8511, Japan. masahikoyazawa@gmail.com.ORCID http://orcid.org/0000-0002-3907-5347

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSome living kidney donors (LKDs) experience proteinuria after donation. Based on several studies, preoperative non-donated side kidney volume (pre-KV) and postoperative percentage change in preserved kidney hypertrophy (%PKH) are associated with proteinuria. This study explored the association of the combination of pre-KV and %PKH with new-onset proteinuria.

methodsThis single-center, retrospective, observational study included eligible LKDs who underwent donor nephrectomy between January 2008 and July 2022 (N = 195). Among those, LKDs in whom KV and either urinary protein or albumin were obtained both pre-donation and 1 year post-donation were finally included (N = 70). The LKDs were assigned to four groups according to the mean body surface area-adjusted pre-KV and %PKH, and their association with the occurrence of proteinuria or albuminuria was investigated.

resultsAmong the 70 LKDs, mean age was 59.8 ± 7.9 years, and 50 (71.4%) were females. The mean preoperative estimated glomerular filtration rate, %PKH, and pre-KV was 78.0 ± 13.6 mL/min/1.73 m

conclusionsProteinuria is more likely to occur postoperatively in LKDs whose kidneys are already enlarged before donation and cannot appropriately hypertrophy.

Indexed as

KidneyKidney TransplantationLiving DonorsNephrectomyProteinuriaAdultAgedAlbuminuriaFemaleGlomerular Filtration RateHumansHypertrophyMaleMiddle AgedOrgan SizeRetrospective StudiesKidney volumeLiving kidney donorProteinuriaVolumetry

Identifiers

PMID39934590

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.