Evidence map›Paper›PMID 39934560›Full record

ArticleMolecular neurobiology2025

Inhibition of Semaphorin 3A in Hippocampus Alleviates Postpartum Depression-Like Behaviors in Mice.

Qing Chen, Fang Xu, Hui Wu, Linghua Xie, Hua Li, Cuicui Jiao, Honghai Zhang, Xinzhong Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qing Chen *Department of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China.
Fang Xu *Department of Anesthesiology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400010, China.
Hui WuDepartment of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China.
Linghua XieDepartment of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China.
Hua LiDepartment of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China.
Cuicui JiaoDepartment of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China.
Honghai ZhangDepartment of Anesthesiology, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, 310006, China.
Xinzhong ChenDepartment of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China. chenxinz@zju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Postpartum depression (PPD) is a widespread psychiatric condition affecting up to 20% of postpartum women. Although it is known to be associated with ovarian hormone withdrawal following delivery, current treatments remain limited due to a lack of underlying mechanism. Here, in mice, we identified that semaphorin 3A (sema3A) exhibited a notable increase in expression within the hippocampus of postpartum depression mice, whereas no such upregulation was observed in female mice experiencing depression induced by lipopolysaccharide or chronic restraint stress. The coexpression rate of sema3A and c-Fos was also elevated in the hippocampal CA3 of postpartum depression mice. Importantly, systemic inhibition or genetic knockdown of hippocampal sema3A significantly alleviated the depressive symptoms induced by ovarian hormone withdrawal. Further, overexpression of sema3A in CA3 induced depressive-like behaviors in naïve female mice. In conclusion, our cumulative findings suggest that sema3A in hippocampal CA3 plays a pivotal role in the pathogenesis of postpartum depression, and could serve as a promising treatment target for ameliorating this widespread disorder.

Indexed as

Behavior, AnimalDepression, PostpartumHippocampusSemaphorin-3AAnimalsCA3 Region, HippocampalFemaleMiceMice, Inbred C57BLProto-Oncogene Proteins c-fosProto-Oncogene Proteins c-fosSemaphorin-3AHippocampusOvarian hormone withdrawalPostpartum depressionSemaphorin 3A

Identifiers

PMID39934560
PMCPMC12078365

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.