Evidence map›Paper›PMID 39934557›Full record

ArticleHormones (Athens, Greece)2025

Effects of aqueous extract from Cyathula prostrata (Linn.) Blume (Amaranthaceae) on puberty onset and some reproductive parameters in immature female Wistar rats.

Landry Lienou Lienou, Marie Stephanie Chekem Goka, Richard Tagne Simo, Fabrice Fabien Dongmo Dongho, Rosalie Annie Ngane Ngono, Ana Paula Ribeiro Rodrigues, Phélix Bruno Telefo

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Article in Hormones (Athens, Greece), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Landry Lienou LienouDepartment of Biochemistry, Faculty of Sciences, University of Douala, P.O. Box: 24157, Douala, Cameroon. lienoulandry@yahoo.fr.ORCID http://orcid.org/0000-0002-6369-0315
Marie Stephanie Chekem GokaResearch Unit in Medicinal Plants, Food Substances and Nutrition, Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
Richard Tagne SimoDepartment of Biomedical Sciences, University of Ngaoundere, P.O. Box 454, Ngaoundere, Cameroon.
Fabrice Fabien Dongmo DonghoDepartment of Biochemistry, Faculty of Sciences, University of Douala, P.O. Box: 24157, Douala, Cameroon.
Rosalie Annie Ngane NgonoDepartment of Biochemistry, Faculty of Sciences, University of Douala, P.O. Box: 24157, Douala, Cameroon.
Ana Paula Ribeiro RodriguesFaculty of Veterinary Sciences, State University of Céara, LAMOFOPA, Fortaleza, Céara State, Brazil.
Phélix Bruno TelefoResearch Unit in Medicinal Plants, Food Substances and Nutrition, Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCyathula prostrata (C. prostrata) a medicinal plant from tropical Africa, is traditionally used in Western Cameroon to treat female infertility. This study investigated the hormone-like effects of the aqueous extract of C. prostrata (AECp) leaves and stems on the onset of puberty and various reproductive parameters in immature female Wistar rats.

methodsFive groups of immature female rats received daily oral doses of AECp for 20 consecutive days. Post-treatment body, ovarian, and uterine weights were recorded, along with uterine and ovarian protein levels, ovarian cholesterol levels, and blood hormone concentrations (FSH, LH, estradiol, and progesterone).

resultsAECp increased the growth rate in all treated animals. It reduced the age at vaginal opening by 2 to 6 days compared to controls. Secondary and tertiary follicles increased by 32.7% and 37.7%, respectively, in AECp-treated rats (96 mg/kg and 64 mg/kg). AECp significantly reduced uterine and ovarian protein levels by 21.3% and 27.8% at 64 mg/kg dosage. Regardless of dose, AECp lowered ovarian cholesterol and serum FSH levels (p < 0.001). Serum progesterone, estradiol, and LH levels increased significantly at 64 mg/kg compared to controls.

conclusionThis study demonstrates AECp's positive effects on the onset of puberty and ovarian folliculogenesis in immature female rats.

Indexed as

OvaryPlant ExtractsReproductionSexual MaturationAnimalsEstradiolFemaleLuteinizing HormoneProgesteroneRatsRats, WistarUterusEstradiolLuteinizing HormonePlant ExtractsProgesteroneCyathula prostrateFollicle stimulating effectInfertilityPuberty onsetSteroidogenesis

Identifiers

PMID39934557

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.