Evidence map›Paper›PMID 39934492›Full record

ArticleJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2025

Loganic Acid Alleviates the Olfactory-Brain NLRP3 Inflammasome Activation and Rescues Dopaminergic Neurons in Experimental Models of Parkinson's Disease.

Samir Ranjan Panda, Pallabi Panja, Meenakshi Singh, Ujjawal Soni, Bishal Rajdev, Pankaj Garg, Sharad D Pawar, Rabinarayan Acharya, Anagha Ranade, V G M Naidu

Abstract read
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In one paragraph

Article in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Samir Ranjan Panda *Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, Sila Katamur, Halugurisuk P.O-Changsari, Assam, 781101, India.
Pallabi Panja *Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, Sila Katamur, Halugurisuk P.O-Changsari, Assam, 781101, India.
Meenakshi SinghDepartment of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, Sila Katamur, Halugurisuk P.O-Changsari, Assam, 781101, India.
Ujjawal SoniDepartment of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, Sila Katamur, Halugurisuk P.O-Changsari, Assam, 781101, India.
Bishal RajdevDepartment of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, Sila Katamur, Halugurisuk P.O-Changsari, Assam, 781101, India.
Pankaj GargDepartment of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, Sila Katamur, Halugurisuk P.O-Changsari, Assam, 781101, India.
Sharad D PawarRegional Ayurveda Institute for Fundamental Research, Pune, Maharashtra, India.
Rabinarayan AcharyaCentral Council for Research in Ayurvedic Science, Ministry of AYUSH, New Delhi, 110058, India.
Anagha RanadeCentral Council for Research in Ayurvedic Science, Ministry of AYUSH, New Delhi, 110058, India.
V G M NaiduDepartment of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, Sila Katamur, Halugurisuk P.O-Changsari, Assam, 781101, India. vgmnaidu@gmail.com.

Funding

Dr. V.G. M Naidu F.No. HQ-PROJ011/14/2022-PROJ
6 · The paper itself

Abstract

The NLRP3 inflammasome signaling cascade activation is a significant contributor to the initiation and progression of Parkinson's disease (PD). Recent evidence supports that targeting NLRP3 inflammasome assembly could be a potential strategy to halt PD progression. The molecular mechanism of the olfactory-brain axis in mediating PD remains elusive. The current study explores that MPTP exposure to C57BL/6 mice leads to glial cell activation and impairs the olfactory function. The role of NLRP3 inflammasome activation in the olfactory bulb and the brain mediating neuroinflammation and neurodegeneration by activating multiple inflammatory pathways is explored. Loganic acid (LA), an iridoid glycoside, has been shown to provide antioxidant, anti-inflammatory, and inhibit microglial activation. Our results in-vitro studies demonstrated that LA treatment in MPP

Indexed as

Dopaminergic NeuronsInflammasomesIridoidsNLR Family, Pyrin Domain-Containing 3 ProteinOlfactory BulbAnimalsMaleMiceMice, Inbred C57BLMicrogliaInflammasomesIridoidsNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseComputational studiesLoganic acidMicrogliaNLRP3 inflammasomeOlfactory bulbParkinson’s diseaseSubstantia nigra

Identifiers

PMID39934492

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.