Evidence map›Paper›PMID 39934454›Full record

ArticleMolecular biology reports2025

Suppression of SIGMAR1 hinders oral cancer cell growth via modulation of mitochondrial Ca

Pablo Shimaoka Chagas, Cristiana Bernadelli Garcia, Henrique Izumi Shimaoka Chagas, W Andrew Yeudall, Jack C Yu, Babak Baban, Andréia Machado Leopoldino

Abstract read
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In one paragraph

Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Next Generation Calcium Nanomaterials: Disrupting Tumor CaInternational journal of nanomedicine · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pablo Shimaoka ChagasDepartment of Clinical Analyses, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. do Café s/n, Ribeirão Preto, 14040-903, SP, Brazil. pablochagas@usp.br.
Cristiana Bernadelli GarciaDepartment of Clinical Analyses, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. do Café s/n, Ribeirão Preto, 14040-903, SP, Brazil.
Henrique Izumi Shimaoka ChagasDepartment of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, 30912, Augusta, GA, USA.
W Andrew YeudallDepartment of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, 30912, Augusta, GA, USA.
Jack C YuDepartment of Surgery, Medical College of Georgia, Augusta University, 30912, Augusta, GA, USA.
Babak BabanDepartment of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, 30912, Augusta, GA, USA.
Andréia Machado LeopoldinoDepartment of Clinical Analyses, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. do Café s/n, Ribeirão Preto, 14040-903, SP, Brazil.

Funding

Fundação de Amparo a Pesquisa do Estado de São Paulo 2016/19103-2Fundação de Amparo a Pesquisa do Estado de São Paulo 2021/03732-9
6 · The paper itself

Abstract

backgroundOral cancer is the most common malignancy of the oral cavity and facial region, affecting the mucosal and epithelial surfaces in the mouth and lips. Unfortunately, OC is often associated with a high mortality rate and limited treatment options for patients. METHODS AND

resultsHerein, we used in silico analysis and in vitro assays to investigate the impact of the Sigma-1 receptor (SIGMAR1) in OC progression by evaluating mitochondrial function, calcium signaling and clonogenic growth. First, the data from the TCGA pan-cancer analysis revealed that SIGMAR1 was overexpressed in OC versus healthy tissue and related to a worse survival rate. Furthermore, we demonstrated that SIGMAR1 silencing led to an increase in mitochondrial membrane potential, a reduction in cellular ATP levels, inhibition of Ca²⁺ influx, and a significant decrease in the clonogenic growth of OC cells.

conclusionsBased on these findings, we suggest that SIGMAR1 may influence mitochondrial membrane potential and energy production by modulating Ca

Indexed as

CalciumMitochondriaMouth NeoplasmsReceptors, sigmaCalcium SignalingCell Line, TumorCell ProliferationCell SurvivalGene Expression Regulation, NeoplasticHumansMembrane Potential, MitochondrialSigma-1 ReceptorCalciumReceptors, sigmaSigma-1 ReceptorMitochondrial Ca2+ signalingOral cancerSIGMAR1Therapeutic strategy

Identifiers

PMID39934454

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.