Evidence map›Paper›PMID 39934335›Full record

ArticleCommunications biology2025

Long QT syndrome type 3 gain-of-function of Na

Claire Castro, Justine Patin, Cyrielle Jajkiewicz, Franck Chizelle, Cynthia Ore Cerpa, Agnès Tessier, Eva Le Pogam, Imen Fellah, Isabelle Baró, Flavien Charpentier and 1 more

Abstract read
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Claire CastroNantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, F-44000, Nantes, France.ORCID http://orcid.org/0000-0002-6309-1689
Justine PatinNantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, F-44000, Nantes, France.
Cyrielle JajkiewiczNantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, F-44000, Nantes, France.ORCID http://orcid.org/0009-0006-1382-6938
Franck ChizelleNantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, F-44000, Nantes, France.
Cynthia Ore CerpaNantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, F-44000, Nantes, France.
Agnès TessierNantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, F-44000, Nantes, France.ORCID http://orcid.org/0000-0002-3281-9841
Eva Le PogamNantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, F-44000, Nantes, France.
Imen FellahNantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, F-44000, Nantes, France.
Isabelle BaróNantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, F-44000, Nantes, France.ORCID http://orcid.org/0000-0003-4850-4171
Flavien CharpentierNantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, F-44000, Nantes, France.
Mickaël DerangeonNantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, F-44000, Nantes, France. mickael.derangeon@univ-nantes.fr.ORCID http://orcid.org/0000-0003-1831-9901

Funding

Agence Nationale de la Recherche (French National Research Agency) ANR-12-BSV1-0013-01Agence Nationale de la Recherche (French National Research Agency) ANR-19-CE14-0031-02
6 · The paper itself

Abstract

The long QT syndrome type 3 (LQT3) is a cardiac channelopathy caused by gain-of-function mutations in the SCN5A gene, encoding the sodium channel Na

Indexed as

Cardiac Conduction System DiseaseFibroblastsGain of Function MutationHeart VentriclesLong QT SyndromeNAV1.5 Voltage-Gated Sodium ChannelAnimalsCell ProliferationCells, CulturedFibrosisMiceTransforming Growth Factor betaNAV1.5 Voltage-Gated Sodium ChannelScn5a protein, mouseTransforming Growth Factor beta

Identifiers

PMID39934335
PMCPMC11814334

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.