Evidence map›Paper›PMID 39934319›Full record

ArticleEuropean archives of psychiatry and clinical neuroscience2025

Increasing specificity in ADHD genetic association studies during childhood: use of the oxytocin-vasopressin pathway in attentional processes suggests specific mechanism for endophenotypes in the 2004 Pelotas birth (Brazil) cohort.

Laísa Camerini, Thais Martins-Silva, Luís Augusto Rohde, Iná S Santos, Fernando Barros, Júlia Pasqualini Genro, Gabriele Ghisleni, Mara Helena Hutz, Isabel Oliveira, Alicia Matijasevich and 1 more

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In one paragraph

Article in European archives of psychiatry and clinical neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Laísa CameriniPostgraduate Program in Epidemiology, Federal University of Pelotas, Rua Marechal Deodoro, 1160 - 3º Piso, Bairro Centro - Pelotas, RS, Caixa Postal 464, Rio Grande do Sul, 96020-220, Brazil. lcamerinidarosa@gmail.com.ORCID http://orcid.org/0000-0002-4811-7887
Thais Martins-SilvaPostgraduate Program in Epidemiology, Federal University of Pelotas, Rua Marechal Deodoro, 1160 - 3º Piso, Bairro Centro - Pelotas, RS, Caixa Postal 464, Rio Grande do Sul, 96020-220, Brazil.
Luís Augusto RohdeADHD Outpatient Program & Development Psychiatry Program, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande Do Sul, Rio Grande do Sul, Brazil.
Iná S SantosPostgraduate Program in Epidemiology, Federal University of Pelotas, Rua Marechal Deodoro, 1160 - 3º Piso, Bairro Centro - Pelotas, RS, Caixa Postal 464, Rio Grande do Sul, 96020-220, Brazil.
Fernando BarrosPostgraduate Program in Epidemiology, Federal University of Pelotas, Rua Marechal Deodoro, 1160 - 3º Piso, Bairro Centro - Pelotas, RS, Caixa Postal 464, Rio Grande do Sul, 96020-220, Brazil.
Júlia Pasqualini GenroADHD Outpatient Program & Development Psychiatry Program, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande Do Sul, Rio Grande do Sul, Brazil.
Gabriele GhisleniPostgraduate Program in Health and Behavior, Catholic University of Pelotas, Rio Grande do Sul, Brazil.
Mara Helena HutzADHD Outpatient Program & Development Psychiatry Program, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande Do Sul, Rio Grande do Sul, Brazil.
Isabel OliveiraPostgraduate Program in Epidemiology, Federal University of Pelotas, Rua Marechal Deodoro, 1160 - 3º Piso, Bairro Centro - Pelotas, RS, Caixa Postal 464, Rio Grande do Sul, 96020-220, Brazil.
Alicia MatijasevichPostgraduate Program in Epidemiology, Federal University of Pelotas, Rua Marechal Deodoro, 1160 - 3º Piso, Bairro Centro - Pelotas, RS, Caixa Postal 464, Rio Grande do Sul, 96020-220, Brazil.
Luciana Tovo-RodriguesPostgraduate Program in Epidemiology, Federal University of Pelotas, Rua Marechal Deodoro, 1160 - 3º Piso, Bairro Centro - Pelotas, RS, Caixa Postal 464, Rio Grande do Sul, 96020-220, Brazil.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 2400943/2013-1Conselho Nacional de Desenvolvimento Científico e Tecnológico 303042/2018-4Conselho Nacional de Desenvolvimento Científico e Tecnológico 305492/2018-7Conselho Nacional de Desenvolvimento Científico e Tecnológico 308294/2018-1Conselho Nacional de Desenvolvimento Científico e Tecnológico 308319/2021-4Conselho Nacional de Desenvolvimento Científico e Tecnológico 312746/2021-0Conselho Nacional de Desenvolvimento Científico e Tecnológico 313320/2018-7Fundação de Amparo à Pesquisa do Estado de São Paulo 2014/13864-6
6 · The paper itself

Abstract

Attentional executive functions, representing a set of self-regulatory cognitive skills, can be a potential Attention-Deficit/Hyperactivity Disorder (ADHD) endophenotype useful for exploring the huge heterogeneity associated to the disorder. Specific biological pathways like the oxytocin-vasopressin pathway (OT-AVP) can unreel ADHD polygenicity. Here, we test the association between genome-wide ADHD polygenic score (PGS) (ADHD-PGS) and both ADHD symptoms and attentional executive functions in the participants of the 2004 Pelotas (Brazil) birth cohort study (N = 4231). We also investigated whether the OT-AVP genomic pathway (OT/AVP

Indexed as

AttentionAttention Deficit Disorder with HyperactivityEndophenotypesExecutive FunctionNeurophysinsOxytocinVasopressinsBirth CohortBrazilChildCohort StudiesFemaleGenome-Wide Association StudyHumansMaleMultifactorial InheritanceAVP protein, humanNeurophysinsOxytocinProtein PrecursorsVasopressinsADHDAttentional executive functionsEndophenotypesOxytocin/vasopressin signalingPolygenic scores

Identifiers

PMID39934319

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.