Evidence map›Paper›PMID 39934281›Full record

ArticleLeukemia2025

Efficacy of MEK inhibitors in Erdheim-Chester disease: impact of MAPK pathway pathogenic variants.

Aldo A Acosta-Medina, Jithma P Abeykoon, Saurabh Zanwar, Gordon J Ruan, Karen L Rech, Aishwarya Ravindran, N Nora Bennani, Caroline J Davidge-Pitts, Matthew J Koster, Jay H Ryu and 7 more

Abstract read
In one paragraph

Article in Leukemia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Rosai-Dorfman disease withOxford medical case reports · 2026
    Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Aldo A Acosta-MedinaDivision of Hematology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-9414-9153
Jithma P AbeykoonDivision of Hematology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0003-3939-6252
Saurabh ZanwarDivision of Hematology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-5074-8453
Gordon J RuanDivision of Hematology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-6969-9169
Karen L RechDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-6770-2339
Aishwarya RavindranDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID http://orcid.org/0000-0003-4503-440X
N Nora BennaniDivision of Hematology, Mayo Clinic, Rochester, MN, USA.
Caroline J Davidge-PittsDivision of Endocrinology, Diabetes and Nutrition, Mayo Clinic, Rochester, MN, USA.
Matthew J KosterDivision of Rheumatology, Mayo Clinic, Rochester, MN, USA.
Jay H RyuDivision of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-9576-2272
Mithun V ShahDivision of Hematology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-5359-336X
W Oliver TobinMayo Clinic Center for Multiple Sclerosis and Autoimmune Neurology, Department of Neurology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-8141-2394
Robert VassalloDivision of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0003-2328-0255
Jason R YoungDepartment of Radiology, Mayo Clinic, Jacksonville, FL, USA.ORCID http://orcid.org/0000-0001-5351-8266
Ronald S GoDivision of Hematology, Mayo Clinic, Rochester, MN, USA. Go.Ronald@mayo.edu.ORCID http://orcid.org/0000-0002-8284-3495
Gaurav GoyalDivision of Hematology/Oncology, University of Alabama at Birmingham, Birmingham, AL, USA. ggoyal@uabmc.edu.ORCID http://orcid.org/0000-0001-6148-5177
Mayo Clinic - University of Alabama at Birmingham Histiocytosis Working Group

Funding

The Role of Monocytes in non-Hodgkin LymphomaP50CA097274 · NCI · UNIVERSITY OF IOWA · PI LENTZ, STEVEN R · 2002 to 2021
$45.7M
Intravenous VSV virotherapy in lymphomaR01CA262613 · NCI · MAYO CLINIC ROCHESTER · PI BENNANI, NABILA NORA, PENG, KAH-WHYE · 2023 to 2025
$1.8M
NCI NIH HHS P50 CA097274NCI NIH HHS R01 CA262613
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID39934281
PMCPMC11976263

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.