ArticleCommunications biology2025
Machine learning with label-free Raman microscopy to investigate ferroptosis in comparison with apoptosis and necroptosis.
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Decoding the spatiotemporal characteristics of ferroptosis: reshaping tumour therapeutic strategies.Experimental hematology & oncology · 2026Review
- Association Between Iron Overload and the Risk of Ocular Hypertension, Primary Open-Angle Glaucoma, and Normal-Tension Glaucoma.Translational vision science & technology · 2025Article
- The effect of particles on static crystallisation in suspensions: sucrose vs inulin.NPJ science of food · 2025Article
- Targeting Ferroptosis to Eliminate Senescent Cells: Mechanisms and Therapeutic Potential.Aging and disease · 2025Review
- Nanoarchitectonics of Sustainable Food Packaging: Materials, Methods, and Environmental Factors.Materials (Basel, Switzerland) · 2025Review
- Diagnosis and activity prediction of SLE based on serum Raman spectroscopy combined with a two-branch Bayesian network.Frontiers in immunology · 2025Article
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Authors and funding
3 authors.
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Abstract
Human and animal health rely on balancing cell division and cell death to maintain normal homeostasis. This process is accomplished by regulated cell death (RCD), whose imbalance can lead to disease. Currently, the most frequently used method for analyzing RCD is fluorescence microscopy. This method has limitations and potential side effects due to the presence of fluorescent labels. Furthermore, fluorescence often lacks specificity and may have side effects. In the quest to overcome such difficulties, label-free approaches have come into focus.Here, Raman microscopy in combination with machine learning is used to investigate RCDs, where biochemical molecular "fingerprints" are investigated with a focus on the vibrations of atoms in molecules. Three different and unique RCD types with different genetic and biochemical machinery, namely, ferroptosis is studied in comparison with apoptosis, and necroptosis in the murine fibroblast line L929sAhFas. Interestingly, during ferroptosis, a decrease in the wavenumber at 939 cm
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