Evidence map›Paper›PMID 39934172›Full record

ArticleNature communications2025

Fully addressable designer superstructures assembled from one single modular DNA origami.

Johann M Weck, Amelie Heuer-Jungemann

Erratum issuedAbstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Tunable Molecular Photonic Wires via Geometric Control of Excitonically Coupled Cyanine Dimer Relays.The journal of physical chemistry. C, Nanomaterials and interfaces · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Two-dimensional data storage using a DNA molecular register.Frontiers in bioengineering and biotechnology · 2026
    Article
  6. DNA Origami and Its Applications in Synthetic Biology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  7. Article
  8. Unraveling the Folding Dynamics of DNA Origami Structures.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  9. Article
  10. Article
  11. Isothermal assembly of DNA nanostructures.Chemical communications (Cambridge, England) · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Johann M WeckMax Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany and Center for Nanoscience, Ludwig-Maximilians University, Munich, Germany. weck@biochem.mpg.de.ORCID http://orcid.org/0009-0002-5785-5950
Amelie Heuer-JungemannMax Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany and Center for Nanoscience, Ludwig-Maximilians University, Munich, Germany. heuer-jungemann@biochem.mpg.de.ORCID http://orcid.org/0000-0003-3630-6389

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) Emmy Noether program (project no. 427981116)Deutsche Forschungsgemeinschaft (German Research Foundation) SFB1032 (A06)
6 · The paper itself

Abstract

DNA nanotechnology and especially the DNA origami method are primal tools to create precise nanoscale objects. For DNA origami, a long ssDNA scaffold strand is folded by a multitude of smaller staple strands into base-pair accurate shapes, allowing for precise modification and incorporation of guest molecules. However, DNA origami are limited in size, and thus is the area that can be controlled with nanoscale precision. Prior methods of creating larger assemblies were either costly or lacked structural control. Here, we incorporate two methods of modularity into one exemplary modular DNA origami (moDON). The modularity allows for the creation of over 50,000 diverse monomers and subsequently the assembly of a plethora of fully addressable designer superstructures while keeping the construction cost very low. The here-introduced methods for modularity in DNA origami design offer an efficient, cost-effective solution for constructing precisely organized, and fully addressable structures on a variety of scales.

Indexed as

DNADNA, Single-StrandedNanostructuresNanotechnologyNucleic Acid ConformationDNADNA, Single-Stranded

Identifiers

PMID39934172
PMCPMC11814417

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.