ArticleScientific reports2025
Innovative application of ceftriaxone as a quorum sensing inhibitor in Pseudomonas aeruginosa.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Natural Lactone-Based Quorum Sensing Inhibitors Attenuate Virulence in Pseudomonas aeruginosa.Chemistry & biodiversity · 2026Article
- Biogenic synthesis and characterization of selenium nanoparticles by halotolerant Bacillus sonorensis 2MNHR.Applied microbiology and biotechnology · 2026Article
- Aloe vera integrated ZnO/SWCNT/Ag nanocomposites for accelerated wound repair and scar reduction.Journal of materials science. Materials in medicine · 2026Article
- Quorum Sensing and Quorum Quenching in Periodontal Disease: Mechanisms and Therapeutic Potential.Current issues in molecular biology · 2026Review
- Comparison of metabolic profiles, regulatory pathways, and quorum sensing inhibition activity of brown mustard seeds (Brassica juncea L.) post germination and roasting treatments.NPJ science of food · 2025Article
- Anti-QS Strategies AgainstMicroorganisms · 2025Review
- Growth-Phase-Dependent Modulation of Quorum Sensing and Virulence Factors inAntibiotics (Basel, Switzerland) · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pseudomonas aeruginosa is a Gram-negative bacterium that has the potential to induce various healthcare-related infections through its array of virulence factors. The control of virulence factor expression is mainly regulated by a communication process among cells called quorum sensing (QS). Blocking QS could be a viable tactic to suppress virulence factors and reduce pathogenicity without impacting bacterial growth. This approach has the potential to significantly decrease the multiple drug resistance emergence. In this study, we explored the impact of ceftriaxone (CRO), which is a commonly used β-lactam antibiotic, and its metal derivatives on the QS system and virulence factors of both standard strains and clinical isolates of P. aeruginosa. The quorum sensing inhibitory (QSI) activity of CRO and ceftriaxone Nickel complex (CRON) was evaluated. The minimum inhibitory concentration (MIC) was determined and the effect of sub-MICs of CRO and CRON was assessed on P. aeruginosa strains virulence factors. CRO and CRON effectively suppressed the virulence factors of P. aeruginosa strains at sub-MICs, without altering bacterial viability. Additionally, a molecular docking investigation was carried out to identify potential mechanisms of QSI. CRO and CRON exhibited high ICM scores, potentially displacing natural ligands when interacting with LasR, LasI, and PqsR receptors.
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