ArticleNature communications2025
A pathogen effector HaRxL10 hijacks the circadian clock component CHE to perturb both plant development and immunity.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- SPIRAL: A versatile online single time-point circadian analysis platform for rice.Science advances · 2026Article
- Under the Cover of Darkness: A Transcriptomic Exploration of Clubroot During the Night.Plant direct · 2026Article
- 'Candidatus Liberibacter Asiaticus' Effector SECP8 Subverts Salicylic Acid-Mediated Citrus Immunity via a Two-Pronged Impairment of CsTCP15 Dimerization.Plant biotechnology journal · 2026Article
- The core clock transcription factor TOC1 binds directly to defence gene promoters regulating immunity in Arabidopsis.Communications biology · 2026Article
- GEAR: an integrated atlas of gene expression dynamics in Arabidopsis thaliana.Nucleic acids research · 2026Article
- A wireless leaf movement sensor system for early detection of abiotic stresses in Zea mays L.Plant methods · 2025Article
- Transcriptional activation and repression in the plant circadian clock: Revisiting core oscillator feedback loops and output pathways.Plant communications · 2025Review
- Decoding sugarcane smut: the role of effector SsEF83 in fungal virulence and plant interaction.Frontiers in microbiology · 2025Article
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Authors and funding
19 authors.
Funding
Abstract
The intertwining between the life cycle of plants and their pathogens made the plant circadian clock an integral constituent of the plant immune system. Reciprocally, pathogens were also found to perturb the expression pattern of certain clock genes. However, how pathogens influence clock components remains largely unknown. Here we show that an oomycete effector HaRxL10 directly targets Arabidopsis central clock component CCA1 HIKING EXPEDITION (CHE) to manipulate its function. HaRxL10 stabilises CHE by disrupting E3 ligase ZEITLUPE-mediated CHE protein degradation. Surprisingly, the accumulation of CHE does not enhance but rather suppresses CHE function, inhibiting its binding to the downstream gene promoter. HaRxL10 triggers reprogramming of the transcriptome including expression of genes related to circadian oscillations. Moreover, HaRxL10 hijacks CHE to repress plant immunity and manipulate physiological processes, including hypocotyl growth and flowering. Taken together, our study discovers the first plant pathogen effector that directly targets a plant circadian clock component and elucidates the underlying molecular mechanism.
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