Evidence map›Paper›PMID 39934129›Full record

ArticleNature communications2025

FTO-associated osteoclastogenesis promotes alveolar bone resorption in apical periodontitis male rat via the HK1/USP14/RANK pathway.

Yajie Qian, Jing Wu, Weidong Yang, Ruining Lyu, Qiao You, Jingjing Li, Qin He, Yuan Zhuang, Wenmei Wang, Yong Wang and 3 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Glucose metabolism in osteoporosis: A potential therapeutic target (Review).International journal of molecular medicine · 2026
    Review
  4. Article
  5. WTAP Transcriptional Suppression by KLF9 Drives Osteoclastogenesis via MAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  6. Review
  7. FTO-modulated mJournal of translational medicine · 2026
    Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Membrane Vesicles ofMicroorganisms · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yajie Qian *Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing, China.
Jing Wu *Medical School of Nanjing University, Nanjing, China.
Weidong YangNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing, China.
Ruining LyuMedical School of Nanjing University, Nanjing, China.
Qiao YouMedical School of Nanjing University, Nanjing, China.
Jingjing LiNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing, China.
Qin HeNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing, China.
Yuan ZhuangNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing, China.
Wenmei WangNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing, China. wenmei-wang@hotmail.com.
Yong WangMedical School of Nanjing University, Nanjing, China. yongwang@nju.edu.cn.ORCID http://orcid.org/0000-0001-8366-7887
Yanan ZhuNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing, China. zh-yanan@163.com.
Zhiwei WuYunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, College of Pharmacy, Dali University, Dali, China. wzhw@nju.edu.cn.ORCID http://orcid.org/0000-0002-0672-948X
Deyan ChenMedical School of Nanjing University, Nanjing, China. chendeyan@nju.edu.cn.ORCID http://orcid.org/0000-0001-7351-4617

Funding

National Natural Science Foundation of China (National Science Foundation of China) 81900823National Natural Science Foundation of China (National Science Foundation of China) 82201055
6 · The paper itself

Abstract

Alveolar bone resorption (ABR) is a key pathological manifestation in the development of apical periodontitis (AP) and contributes to the AP-associated tooth loss among AP patients in the clinic. However, the underlying mechanism of ABR development is largely unknown. Here we show, the total levels of N6-methyladenosine (m

Indexed as

Alpha-Ketoglutarate-Dependent Dioxygenase FTOAlveolar Bone LossHexokinaseOsteogenesisPeriapical PeriodontitisReceptor Activator of Nuclear Factor-kappa BUbiquitin ThiolesteraseAdenosineAnimalsMaleOsteoclastsRatsRats, Sprague-DawleySignal TransductionAdenosineAlpha-Ketoglutarate-Dependent Dioxygenase FTOHexokinaseN-methyladenosineReceptor Activator of Nuclear Factor-kappa BUbiquitin Thiolesterase

Identifiers

PMID39934129
PMCPMC11814306

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.