Evidence map›Paper›PMID 39933950›Full record

ArticleBiomolecules & therapeutics2025

Isorhamnetin Alleviates Inflammation-Induced Crosstalk between Kynurenine Pathway and Gut Microbiota in Depressed Mice.

Mengjie Xu, Wei He, Ke Yan, Xinru Gao, Jun Li, Dongyue Xu, Jiao Xiao, Tingxu Yan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mengjie XuDepartment of Biological Sciences, XinZhou Normal University, Xinzhou, Shanxi 034000, China.
Wei HeDepartment of Biological Sciences, XinZhou Normal University, Xinzhou, Shanxi 034000, China.
Ke YanDepartment of Biological Sciences, XinZhou Normal University, Xinzhou, Shanxi 034000, China.
Xinru GaoDepartment of Biological Sciences, XinZhou Normal University, Xinzhou, Shanxi 034000, China.
Jun LiDepartment of Biological Sciences, XinZhou Normal University, Xinzhou, Shanxi 034000, China.
Dongyue XuDepartment of Biological Sciences, XinZhou Normal University, Xinzhou, Shanxi 034000, China.
Jiao XiaoWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.
Tingxu YanSchool of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Depression is a widespread psychiatric disorder with complex pathogenesis and unsatisfactory therapeutic effects. As a native flavonoid, Isorhamnetin (ISO) has been deemed to exert neuroprotective effects by antioxidation and regulation of immunity. However, no reports of anti-depressed effect of ISO have yet been found. The present study was conducted to clarify the mechanism basis of anti-depressed effect of ISO utilizing behavioral, biochemical, molecular approaches

Indexed as

DepressionGut microbiotaInflammationIsorhamnetinKynurenine pathway

Identifiers

PMID39933950
PMCPMC11893487

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.