Evidence map›Paper›PMID 39933923›Full record

ArticleLife science alliance2025

Canonical and non-canonical PRC1 differentially contribute to regulation of neural stem cell fate.

Janine Hoffmann, Theresa M Schütze, Annika Kolodziejczyk, Karolin Küster, Annekathrin Kränkel, Susanne Reinhardt, Razvan P Derihaci, Cahit Birdir, Pauline Wimberger, Haruhiko Koseki and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Janine HoffmannCenter for Regenerative Therapies Dresden, TUD Dresden University of Technology, Dresden, Germany.ORCID 0000-0002-1595-5411
Theresa M SchützeCenter for Regenerative Therapies Dresden, TUD Dresden University of Technology, Dresden, Germany.
Annika KolodziejczykCenter for Regenerative Therapies Dresden, TUD Dresden University of Technology, Dresden, Germany.ORCID 0000-0003-4447-2563
Karolin KüsterCenter for Regenerative Therapies Dresden, TUD Dresden University of Technology, Dresden, Germany.
Annekathrin KränkelDRESDEN-Concept Genome Center, Center for Molecular and Cellular Bioengineering, Technology Platform of the TUD Dresden University of Technology, Dresden, Germany.
Susanne ReinhardtDRESDEN-Concept Genome Center, Center for Molecular and Cellular Bioengineering, Technology Platform of the TUD Dresden University of Technology, Dresden, Germany.ORCID 0000-0001-9202-105X
Razvan P DerihaciDepartment of Gynecology and Obstetrics, Technische Universität Dresden, Dresden, Germany.
Cahit BirdirDepartment of Gynecology and Obstetrics, Technische Universität Dresden, Dresden, Germany.
Pauline WimbergerDepartment of Gynecology and Obstetrics, Technische Universität Dresden, Dresden, Germany.
Haruhiko KosekiLaboratory of Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID 0000-0001-8424-5854
Mareike AlbertCenter for Regenerative Therapies Dresden, TUD Dresden University of Technology, Dresden, Germany mareike.albert@tu-dresden.de.ORCID 0000-0001-9855-9344

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neocortex development is characterized by sequential phases of neural progenitor cell (NPC) expansion, neurogenesis, and gliogenesis. Polycomb-mediated epigenetic mechanisms are known to play important roles in regulating the lineage potential of NPCs during development. The composition of Polycomb repressive complex 1 (PRC1) is highly diverse in mammals and was hypothesized to contribute to context-specific regulation of cell fate. Here, we have performed a side-by-side comparison of the role of canonical PRC1.2/1.4 and non-canonical PRC1.3/1.5, all of which are expressed in the developing neocortex, in NSC proliferation and differentiation. We found that the deletion of

Indexed as

Neural Stem CellsPolycomb Repressive Complex 1AnimalsCell DifferentiationCell LineageCell ProliferationGene Expression Regulation, DevelopmentalMiceNeocortexNeurogenesisPolycomb Repressive Complex 1

Identifiers

PMID39933923
PMCPMC11814486

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.