Evidence map›Paper›PMID 39933777›Full record

ArticleSaudi medical journal2025

Prevalence and clinical considerations of Y chromosome microdeletions in azoospermic and oligozoopsermic infertile men from Al Madinah Al Munawarah, Saudi Arabia.

Monis B Shamsi, Rima Dada, Reham M Balahmar, Dimah Zaytuni, Ghadeer Alharbi, Syed N Imam, Emad Rajih, Muhammad Latif, Saif Ahmad

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Saudi medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Monis B ShamsiFrom the Center for Genetics and Inherited Diseases (Shamsi, Balahmar, Zaytuni, Alharbi, Latif); from the Department of Basic Medical Sciences (Shamsi, Imam, Latif); from the Department of General and Specialized Surgery (Rajih), College of Medicine, Taibah University, Al-Madinah Al-Munawarah, Kingdom of Saudi Arabia, from the Department of Anatomy (Dada), Laboratory of Molecular Reproduction & Genetics, All India Institute of Medical Sciences, New Delhi, India, and from the Department of Translational Neuroscience (Ahmad), Barrow Neurological Institute, Phoenix, United States of America.ORCID https://orcid.org/0000-0003-2158-6349
Rima DadaFrom the Center for Genetics and Inherited Diseases (Shamsi, Balahmar, Zaytuni, Alharbi, Latif); from the Department of Basic Medical Sciences (Shamsi, Imam, Latif); from the Department of General and Specialized Surgery (Rajih), College of Medicine, Taibah University, Al-Madinah Al-Munawarah, Kingdom of Saudi Arabia, from the Department of Anatomy (Dada), Laboratory of Molecular Reproduction & Genetics, All India Institute of Medical Sciences, New Delhi, India, and from the Department of Translational Neuroscience (Ahmad), Barrow Neurological Institute, Phoenix, United States of America.
Reham M BalahmarFrom the Center for Genetics and Inherited Diseases (Shamsi, Balahmar, Zaytuni, Alharbi, Latif); from the Department of Basic Medical Sciences (Shamsi, Imam, Latif); from the Department of General and Specialized Surgery (Rajih), College of Medicine, Taibah University, Al-Madinah Al-Munawarah, Kingdom of Saudi Arabia, from the Department of Anatomy (Dada), Laboratory of Molecular Reproduction & Genetics, All India Institute of Medical Sciences, New Delhi, India, and from the Department of Translational Neuroscience (Ahmad), Barrow Neurological Institute, Phoenix, United States of America.
Dimah ZaytuniFrom the Center for Genetics and Inherited Diseases (Shamsi, Balahmar, Zaytuni, Alharbi, Latif); from the Department of Basic Medical Sciences (Shamsi, Imam, Latif); from the Department of General and Specialized Surgery (Rajih), College of Medicine, Taibah University, Al-Madinah Al-Munawarah, Kingdom of Saudi Arabia, from the Department of Anatomy (Dada), Laboratory of Molecular Reproduction & Genetics, All India Institute of Medical Sciences, New Delhi, India, and from the Department of Translational Neuroscience (Ahmad), Barrow Neurological Institute, Phoenix, United States of America.
Ghadeer AlharbiFrom the Center for Genetics and Inherited Diseases (Shamsi, Balahmar, Zaytuni, Alharbi, Latif); from the Department of Basic Medical Sciences (Shamsi, Imam, Latif); from the Department of General and Specialized Surgery (Rajih), College of Medicine, Taibah University, Al-Madinah Al-Munawarah, Kingdom of Saudi Arabia, from the Department of Anatomy (Dada), Laboratory of Molecular Reproduction & Genetics, All India Institute of Medical Sciences, New Delhi, India, and from the Department of Translational Neuroscience (Ahmad), Barrow Neurological Institute, Phoenix, United States of America.
Syed N ImamFrom the Center for Genetics and Inherited Diseases (Shamsi, Balahmar, Zaytuni, Alharbi, Latif); from the Department of Basic Medical Sciences (Shamsi, Imam, Latif); from the Department of General and Specialized Surgery (Rajih), College of Medicine, Taibah University, Al-Madinah Al-Munawarah, Kingdom of Saudi Arabia, from the Department of Anatomy (Dada), Laboratory of Molecular Reproduction & Genetics, All India Institute of Medical Sciences, New Delhi, India, and from the Department of Translational Neuroscience (Ahmad), Barrow Neurological Institute, Phoenix, United States of America.
Emad RajihFrom the Center for Genetics and Inherited Diseases (Shamsi, Balahmar, Zaytuni, Alharbi, Latif); from the Department of Basic Medical Sciences (Shamsi, Imam, Latif); from the Department of General and Specialized Surgery (Rajih), College of Medicine, Taibah University, Al-Madinah Al-Munawarah, Kingdom of Saudi Arabia, from the Department of Anatomy (Dada), Laboratory of Molecular Reproduction & Genetics, All India Institute of Medical Sciences, New Delhi, India, and from the Department of Translational Neuroscience (Ahmad), Barrow Neurological Institute, Phoenix, United States of America.
Muhammad LatifFrom the Center for Genetics and Inherited Diseases (Shamsi, Balahmar, Zaytuni, Alharbi, Latif); from the Department of Basic Medical Sciences (Shamsi, Imam, Latif); from the Department of General and Specialized Surgery (Rajih), College of Medicine, Taibah University, Al-Madinah Al-Munawarah, Kingdom of Saudi Arabia, from the Department of Anatomy (Dada), Laboratory of Molecular Reproduction & Genetics, All India Institute of Medical Sciences, New Delhi, India, and from the Department of Translational Neuroscience (Ahmad), Barrow Neurological Institute, Phoenix, United States of America.
Saif AhmadFrom the Center for Genetics and Inherited Diseases (Shamsi, Balahmar, Zaytuni, Alharbi, Latif); from the Department of Basic Medical Sciences (Shamsi, Imam, Latif); from the Department of General and Specialized Surgery (Rajih), College of Medicine, Taibah University, Al-Madinah Al-Munawarah, Kingdom of Saudi Arabia, from the Department of Anatomy (Dada), Laboratory of Molecular Reproduction & Genetics, All India Institute of Medical Sciences, New Delhi, India, and from the Department of Translational Neuroscience (Ahmad), Barrow Neurological Institute, Phoenix, United States of America.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo characterize the potential role of Y-chromosome microdeletion (YCM) as a genetic cause for infertility in the Arab population from the Al Madinah Al Munawarah.

methodsWe screened 97 infertile men from Al Madinah Al Munawarah, from February 2022 to March 2024. Genomic blood DNA was analyzed for 8 sequence tagged site (STS) markers of Y chromosome by multiplex polymerase chain reaction.

resultsWe found microdeletions in 3 infertile men, indicating a prevalence of 3.1%. The STS markers sY254 and sY255 corresponding to AZFc regions were deleted in these men. No deletion was observed in any other STS markers investigated in this study.

conclusionOur findings for prevalence in Arab population of Al Madinah Al Munawarah is comparable to other studies from Saudi Arabia. However, large variance in the prevalence of YCM in the Arab population of other Middle Eastern countries is reportedly observed. The YCM has significant prognostic value, since it indicates the spermatogenic profile, the success probability of assisted reproduction technique (ART) procedures as testicular sperm extraction and apprise of potential risk of vertical transmission of microdeletion from father to son in patients opting for ART. With these considerations, we re-emphasize the need for genetic screening of YCM in azoo- and oligozoospermic infertile men.

Indexed as

AzoospermiaChromosome DeletionChromosomes, Human, YInfertility, MaleOligospermiaSex Chromosome Disorders of Sex DevelopmentAdultHumansMalePrevalenceSaudi ArabiaSequence Tagged SitesSex Chromosome Aberrationsazoospermiamale infertilityoligozoospermiaSTS markersY chromosome microdeletions

Identifiers

PMID39933777
PMCPMC11822931

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.