Evidence map›Paper›PMID 39933768›Full record

ArticleSaudi medical journal2025

Association between factor I fibrinogen (rs6050) and factor XI plasma thromboplastin (rs4253417) genetic polymorphisms and recurrent spontaneous miscarriage in Saudi women.

Aaishah M Kaabi, Afrah F Alkhuriji, Zeneb A Babay, Ibrahim A Barakat, Abdullah M Kaabi, Reem M Kaabi

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Article in Saudi medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

6 authors.

Aaishah M KaabiFrom the Department of Zoology (Aaishah Kaabi, Al-Khuriji), College of Science; from the Department of Obstetrics and Gynecology (Babay)King Saud University; from the Central Military Laboratory & Blood Bank (Abdullah Kaabi), Prince Sultan Military Medical City, Riyadh; and from the Department of Laboratory and Blood Bank (Reem Kaabi), Al-Bukayriyah General Hospital, Qassim, Kingdom Saudi Arabia; and from the Cell Biology Department (Barakat), National Research Center, Giza, Egypt.ORCID https://orcid.org/0000-0002-9630-1718
Afrah F AlkhurijiFrom the Department of Zoology (Aaishah Kaabi, Al-Khuriji), College of Science; from the Department of Obstetrics and Gynecology (Babay)King Saud University; from the Central Military Laboratory & Blood Bank (Abdullah Kaabi), Prince Sultan Military Medical City, Riyadh; and from the Department of Laboratory and Blood Bank (Reem Kaabi), Al-Bukayriyah General Hospital, Qassim, Kingdom Saudi Arabia; and from the Cell Biology Department (Barakat), National Research Center, Giza, Egypt.
Zeneb A BabayFrom the Department of Zoology (Aaishah Kaabi, Al-Khuriji), College of Science; from the Department of Obstetrics and Gynecology (Babay)King Saud University; from the Central Military Laboratory & Blood Bank (Abdullah Kaabi), Prince Sultan Military Medical City, Riyadh; and from the Department of Laboratory and Blood Bank (Reem Kaabi), Al-Bukayriyah General Hospital, Qassim, Kingdom Saudi Arabia; and from the Cell Biology Department (Barakat), National Research Center, Giza, Egypt.
Ibrahim A BarakatFrom the Department of Zoology (Aaishah Kaabi, Al-Khuriji), College of Science; from the Department of Obstetrics and Gynecology (Babay)King Saud University; from the Central Military Laboratory & Blood Bank (Abdullah Kaabi), Prince Sultan Military Medical City, Riyadh; and from the Department of Laboratory and Blood Bank (Reem Kaabi), Al-Bukayriyah General Hospital, Qassim, Kingdom Saudi Arabia; and from the Cell Biology Department (Barakat), National Research Center, Giza, Egypt.
Abdullah M KaabiFrom the Department of Zoology (Aaishah Kaabi, Al-Khuriji), College of Science; from the Department of Obstetrics and Gynecology (Babay)King Saud University; from the Central Military Laboratory & Blood Bank (Abdullah Kaabi), Prince Sultan Military Medical City, Riyadh; and from the Department of Laboratory and Blood Bank (Reem Kaabi), Al-Bukayriyah General Hospital, Qassim, Kingdom Saudi Arabia; and from the Cell Biology Department (Barakat), National Research Center, Giza, Egypt.
Reem M KaabiFrom the Department of Zoology (Aaishah Kaabi, Al-Khuriji), College of Science; from the Department of Obstetrics and Gynecology (Babay)King Saud University; from the Central Military Laboratory & Blood Bank (Abdullah Kaabi), Prince Sultan Military Medical City, Riyadh; and from the Department of Laboratory and Blood Bank (Reem Kaabi), Al-Bukayriyah General Hospital, Qassim, Kingdom Saudi Arabia; and from the Cell Biology Department (Barakat), National Research Center, Giza, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo identify genetic polymorphisms in factor I fibrinogen (rs6050) and factor XI plasma thromboplastin (rs4253417) in Saudi women with recurrent spontaneous miscarriage (RSM). Furthermore, to compare the levels of clotting factors in the blood of patients and healthy controls.

methodsThe current study was conducted at the King Khalid University Hospital in Riyadh, Saudi Arabia, from September 2022 to June 2023. The study involved 100 Saudi women, 50 pregnant and 50 non-pregnant individuals, who experienced RSM. Furthermore, 100 healthy Saudi women, including 50 pregnant and 50 non-pregnant individuals, were also included as controls. TaqMan genotyping assays were used to determine single nucleotide polymorphisms in the promoter regions of the factor I and XI genes.

resultsA significant correlation was found between the Factor I fibrinogen genotype (rs6050 C/T) and RSM in non-pregnant Saudi women. However, no significant correlation was observed between the Factor XI polymorphism (rs4253417 C/T) and RSM.

conclusionWe demonstrated a significant correlation between genetic polymorphisms in factor I fibrinogen in certain genes studied and RSM. This association could be attributed to changes in fibrinogen levels, which impact the coagulation process and lead to an increase in thrombotic events, which are recognized as risk factors for miscarriage. Notably, variations in the other genes examined did not exhibit any association with the risk of RSM.

Indexed as

Abortion, HabitualFactor XIFibrinogenPolymorphism, Single NucleotideAdultCase-Control StudiesFemaleGenetic Predisposition to DiseaseGenotypeHumansPregnancySaudi ArabiaFactor XIFibrinogenclotting factorsfactor I fibrinogenfactor XI plasma thromboplastingenomic DNARecurrent spontaneous miscarriageSingle-nucleotide polymorphisms (SNPs)TaqMan assay

Identifiers

PMID39933768
PMCPMC11822937

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.