Trial reportBMJ (Clinical research ed.)2025
Effect of high flow nasal cannula oxygenation on incidence of hypoxia during sedated gastrointestinal endoscopy in patients with obesity: multicentre randomised controlled trial.
Trial report in BMJ (Clinical research ed.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04500392 (High-flow Nasal Cannula Oxygenation Decrease Hypoxia in Sedated Gastrointestinal Endoscopes in Obesity), which is not on this map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
High-flow Nasal Cannula Oxygenation Decrease Hypoxia in Sedated Gastrointestinal Endoscopes in Obesity: a Randomized Multicenter Clinical Trial
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and safety of endoscopy-specific dual-channel supraglottic airways for upper gastrointestinal endoscopic and transesophageal instrumentation procedures: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- High-flow nasal cannula oxygenation in sedated endoscopy for high-risk obstructive sleep apnea patients: study protocol for a multicentre randomised controlled trial.Annals of medicine · 2026Trial
- Combination of COMBO endoscopy oropharyngeal airway and high-flow nasal cannula oxygenation in sedated gastrointestinal endoscopy for morbidly obese patients: a Simon two-stage trial.BMC anesthesiology · 2026Trial
- Dixon Up-and-Down Method for Optimizing Oxycodone Dosage in Painless Colonoscopy.Journal of pain research · 2026Trial
- Ciprofol versus Propofol Combined with Alfentanil for Respiratory Adverse Events in Overweight Patients Undergoing Painless Gastroscopy: A Randomized Controlled Trial.Drug design, development and therapy · 2026Trial
- Comparison of the Effect of Different Administration Sequence of Propofol and Remifentanil on Sedation/Anesthesia During Gastroscopy in Obese Patients.Drug design, development and therapy · 2026Trial
- Effect of anesthetic nasal mask on hypoxemia in elderly patients undergoing gastroscopy with deep sedation: a randomized controlled trial.BMC gastroenterology · 2025Trial
- Effect of nasal mask oxygenation on incidence of hypoxemia during gastroscopy with propofol sedation in patients at risk of hypoxemia: a prospective randomized controlled study.BMC anesthesiology · 2025Trial
- Efficacy of a nasal mask oxygen kit versus regular nasal cannula in sedated gastrointestinal endoscopy: a multicentre, randomised clinical trial.BMJ open gastroenterology · 2025Trial
- A nomogram for predicting sedation-related adverse events in elderly patients undergoing painless gastrointestinal endoscopy.Frontiers in medicine · 2025Trial
- Effects of Fentanyl-Reduced Regimen with Esketamine and Remimazolam on Bronchoscopy in Elderly Patients.Drug design, development and therapy · 2025Trial
- Effects of nine sedative-analgesic combinations on fatigue after gastrointestinal endoscopy: a randomized controlled 3 × 3 factorial trial protocol.Annals of medicine · 2026Article
- High-flow versus standard nasal cannula oxygenation for post-procedural quality of recovery in older adults undergoing sedated ERCP: protocol for a randomized controlled trial.Annals of medicine · 2026Article
- Development and independent validation of a hypoxemia risk prediction model (HAPPY-12K) for sedated gastrointestinal endoscopy: a multicentre prospective cohort study.EClinicalMedicine · 2026Article
- High-Flow Nasal Oxygen in Contemporary Airway Management: Enhancing Physiological Safety in Anaesthesia-A Narrative Review.Healthcare (Basel, Switzerland) · 2026Review
- High-flow nasal cannula oxygen versus Venturi facemask in women with cardiovascular disease undergoing cesarean delivery under neuraxial anesthesia: a randomized controlled trial.Journal of thoracic disease · 2026Article
- Article
- Sedation in Gastrointestinal Endoscopy: From Drug-Centered Protocols to Personalized, Technology-Supported Pathways: A Narrative Review.Journal of clinical medicine · 2026Review
- Review
- Effect of nasopharyngeal airway on hypoxemia in overweight and obese patients undergoing sedated endoscopy: A randomized trial.iScience · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine whether high flow nasal cannula (HFNC) oxygenation can reduce the incidence of hypoxia during sedated gastrointestinal endoscopy in patients with obesity.
designMulticentre, randomised, parallel group trial.
settingThree tertiary hospitals in Shanghai, China.
participants1000 adult patients with obesity (body mass index ≥28) who were scheduled for gastrointestinal endoscopy.
interventionsParticipants were randomly allocated to receive regular nasal cannula oxygenation or HFNC oxygenation during a sedated procedure with propofol and low dose sufentanil.
main outcome measuresThe primary outcome was the incidence of hypoxia (75%≤SpO
resultsFrom 6 May 2021 to 26 May 2023, 984 patients (mean age 49.2 years; 36.9% (n=363) female) completed the study and were analysed. Compared with regular nasal cannula oxygenation, HFNC oxygenation reduced the incidence of hypoxia from 21.2% (103/487) to 2.0% (10/497) (difference -19.14, 95% confidence interval -23.09 to -15.36; P<0.001), subclinical respiratory depression from 36.3% (177/487) to 5.6% (28/497) (difference -30.71, -35.40 to -25.92; P<0.001), and severe hypoxia from 4.1% (20/487) to 0% (0/497) (difference -4.11%, -6.26 to -2.48; P<0.001). Other sedation related adverse events did not differ between the two groups.
conclusionsIn patients with obesity, oxygenation via HFNC during sedated gastrointestinal endoscopy significantly reduced the incidences of hypoxia, subclinical respiratory depression, and severe hypoxia without increasing other adverse events.
trial registrationClinicalTrials.gov NCT04500392.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.