ArticleJornal de pediatria
Lessons of screening two million newborns for congenital adrenal hyperplasia: 10-year experience of the Minas Gerais Public Health Program.
Article in Jornal de pediatria. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Xp21 contiguous gene deletion syndrome presenting as congenital adrenal hypoplasia: molecular diagnosis and clinical re-evaluation of a pedigree.Frontiers in endocrinology · 2026Article
- A public health success: newborn screening for congenital adrenal hyperplasia in a middle-income Brazilian state.Jornal de pediatriaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis is a 10-year period, descriptive and retrospective evaluation of a Brazilian State NBS-CAH public program, bringing light to the prior discussion concerning its implementation, by sharing the screening-240,000 babies annually practices.
methodsThe Minas Gerais (MG) NBS program has been coordinated by NUPAD, a neonatal screening, monitoring care, and genetics center at the Federal University of Minas Gerais (UFMG), intermediating all necessary actions, under the management of the State Health Administration, and following the Brazilian universal program. The dataset was used to calculate sensitivity, specificity, positive predictive value (PPV), incidence, number of carriers, and false-positive rates.
resultsAbout 2,094,588 newborns were screened, and the incidence was 1:14,647; PPV was 10.5%. Most samples were collected on the fifth day after birth (interquartile range 4-6 days); 1352 babies were referred for clinical evaluation; 1210 were false positives (0.06%), and 142 presented the classic form; 22% of newborns were hospitalized due to salt-loss symptoms before or at the first visit.
conclusionsThe MG NBS-CAH success as a public program comes from the Brazilian unified public health system, with integrated care, and from the newborn screening center offering timely referred screened positive cases and its outstanding state coverage. Appropriate cutoffs and close monitoring of hospitalized newborns have been pivotal for reducing the high false-positive rates.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.