ArticleNeuron2025
Slow cortical dynamics generate context processing and novelty detection.
Article in Neuron, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Protocol for analyzing slow cortical dynamics in mouse neuronal recordings.STAR protocols · 2026Article
- Strong connections of locally clustered neurons in the upper-layer cortex underlie schizophrenia-related auditory deviance detection.Science advances · 2026Article
- Neuronal ensembles in cortical function and disease.Physiological reviews · 2026Review
- Do auditory deviants evoke cortical state changes under anaesthesia? A proof-of-concept study.Experimental physiology · 2026Article
- Behavioral and neural mechanisms underlying contextual processing in naturalistic short video viewing.iScience · 2026Article
- Global context rapidly shapes sensory responses in V1.bioRxiv : the preprint server for biology · 2026Article
- Cortical deviance detection represents a canonical difference signal.bioRxiv : the preprint server for biology · 2026Article
- Recurrent neural network models reveal unified mechanisms generating event-related potentials from MMN to P300.bioRxiv : the preprint server for biology · 2025Article
- The Somatosensory Mismatch Negativity.The European journal of neuroscience · 2025Review
- Mismatch negativity develops in adolescence and independently of microglia.bioRxiv : the preprint server for biology · 2025Article
- Duet model unifies diverse neuroscience experimental findings on predictive coding.bioRxiv : the preprint server for biology · 2025Article
- Irrationality in humans and creativity in AI.Frontiers in artificial intelligence · 2025Review
- The impact of sleep deprivation on cognitive function in healthy adults: insights from auditory P300 and reaction time analysis.Frontiers in neuroscience · 2025Article
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Authors and funding
4 authors.
Funding
Abstract
The cortex amplifies responses to novel stimuli while suppressing redundant ones. Novelty detection is necessary to efficiently process sensory information and build predictive models of the environment, and it is also altered in schizophrenia. To investigate the circuit mechanisms underlying novelty detection, we used an auditory "oddball" paradigm and two-photon calcium imaging to measure responses to simple and complex stimuli across mouse auditory cortex. Stimulus statistics and complexity generated specific responses across auditory areas. Neuronal ensembles reliably encoded auditory features and temporal context. Interestingly, stimulus-evoked population responses were particularly long lasting, reflecting stimulus history and affecting future responses. These slow cortical dynamics encoded stimulus temporal context and generated stronger responses to novel stimuli. Recurrent neural network models trained on the oddball task also exhibited slow network dynamics and recapitulated the biological data. We conclude that the slow dynamics of recurrent cortical networks underlie processing and novelty detection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.