Evidence map›Paper›PMID 39933517›Full record

ArticleCurrent biology : CB2025

Modulation of sweet preference by neurosteroid-sensitive, δ-GABA

Priscilla E Yevoo, Alfredo Fontanini, Arianna Maffei

Abstract read
In one paragraph

Article in Current biology : CB, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Priscilla E YevooDepartment of Neurobiology and Behavior Stony Brook University, Life Science Building, 100 Nicoll Road, Stony Brook, NY 11794-5320, USA; Graduate Program in Neuroscience, Stony Brook University, 100 Nicoll Road, Stony Brook, NY 11794-5320, USA.
Alfredo FontaniniDepartment of Neurobiology and Behavior Stony Brook University, Life Science Building, 100 Nicoll Road, Stony Brook, NY 11794-5320, USA; Graduate Program in Neuroscience, Stony Brook University, 100 Nicoll Road, Stony Brook, NY 11794-5320, USA; Center for Neural Circuit Dynamics, Stony Brook University, Life Science Building, 100 Nicoll Road, Stony Brook, NY 11794-5320, USA.
Arianna MaffeiDepartment of Neurobiology and Behavior Stony Brook University, Life Science Building, 100 Nicoll Road, Stony Brook, NY 11794-5320, USA; Graduate Program in Neuroscience, Stony Brook University, 100 Nicoll Road, Stony Brook, NY 11794-5320, USA; Center for Neural Circuit Dynamics, Stony Brook University, Life Science Building, 100 Nicoll Road, Stony Brook, NY 11794-5320, USA. Electronic address: arianna.maffei@stonybrook.edu.

Funding

Synaptic organization and plasticity of the input from the basolateral amygdala tR01DC013770 · NIDCD · STATE UNIVERSITY NEW YORK STONY BROOK · PI Alfredo Fontanini, Arianna Maffei · 2014 to 2026
$4.6M
Metastable dynamics in cortical circuitsUF1NS115779 · NINDS · STATE UNIVERSITY NEW YORK STONY BROOK · PI BRINKMAN, BRADEN, FONTANINI, ALFREDO · 2020 to 2020
$3.6M
Cortical mechanisms for the postnatal development of taste preference.R01DC019827 · NIDCD · STATE UNIVERSITY NEW YORK STONY BROOK · PI MAFFEI, ARIANNA · 2021 to 2025
$2.4M
Functional role of Gastrin Releasing Peptide (GRP) and GRP expressing neurons in the gustatory cortexR01DC020722 · NIDCD · STATE UNIVERSITY NEW YORK STONY BROOK · PI Alfredo Fontanini · 2023 to 2026
$2.3M
Laminar differences in taste coding: a circuit perspectiveR01DC015234 · NIDCD · STATE UNIVERSITY NEW YORK STONY BROOK · PI FONTANINI, ALFREDO, MAFFEI, ARIANNA · 2016 to 2020
$2.0M
The Role of Extrasynaptic GABAAR Signaling in the Gustatory Cortex on Taste-Dependent Impulsive BehaviorF31DC019518 · NIDCD · STATE UNIVERSITY NEW YORK STONY BROOK · PI YEVOO, PRISCILLA · 2021 to 2023
$117k
NIDCD NIH HHS F31 DC019518NIDCD NIH HHS R01 DC013770NIDCD NIH HHS R01 DC015234NIDCD NIH HHS R01 DC019827NIDCD NIH HHS R01 DC020722NINDS NIH HHS UF1 NS115779
6 · The paper itself

Abstract

Taste preference is a fundamental driver of feeding behavior, influencing dietary choices and eating patterns. Extensive experimental evidence indicates that the gustatory cortex (GC) is engaged in taste perception, palatability, and preference. However, our knowledge of the neural and neurochemical signals regulating taste preference is limited. Neuromodulators can affect preferences, though their effects on neural circuits for taste are incompletely understood. Neurosteroids are of particular interest, as systemic administration of the neurosteroid allopregnanolone (ALLO), a positive allosteric modulator of extrasynaptic GABA

Indexed as

Food PreferencesInsular CortexNeurosteroidsPregnanoloneReceptors, GABA-ATasteTaste PerceptionAnimalsMaleMiceMice, Inbred C57BLNeurosteroidsPregnanoloneReceptors, GABA-Aextrasynaptic transmissionGABA(A)insular cortexneurosteroidstaste

Identifiers

PMID39933517
PMCPMC11903165

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.