ArticlePloS one2025
Association between glycosylated hemoglobin and blood lead: A cross-sectional study.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiabetes is the most common chronic metabolic disease, affecting many people's health. Previous studies have shown a close relationship between trace elements and metabolic diseases. This study investigated the interrelationship between glycosylated hemoglobin (HbA1c) and blood lead (BPb) in adults.
methodThis research was carried out involving 12,049 eligible individuals aged 20 years or above from the National Health and Nutrition Examination Survey (NHANES) spanning from 2011 to 2020. Weighted linear regression models and smoothed curve fitting were employed to investigate the association between HbA1c and blood lead. Analyses were stratified based on age, sex, race, and body mass index, and threshold effects were explored using two-stage segmented linear regression models.
resultAmong all 12049 participants, through comprehensive adjustment of the model, this study discovered a negative association between HbA1c and blood lead. In addition, when stratified by sex, age, race, and BMI status in subgroup analysis in this study, this correlation still had specific statistical significance. In performing subgroup analyses, we found that the relationship between HbA1c and blood lead may yield distinct outcomes arise from gender disparities. In women, a significant U-shaped association exists between HbA1c and BPb. At approximately 6.6% of HbA1c value, the relationship between the two shifts from negative to positive.
conclusionThis investigation proposes a "U" form association between HbA1c and BPb in American adults.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.