ArticlePlant biotechnology journal2025
LsBLH2-LsOFP6-LsKANT3 module regulates bolting by orchestrating the gibberellin biosynthesis and metabolism in lettuce.
Article in Plant biotechnology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- The MdSLR1b-MdKNOX15-MdGA20ox2/MdGA2ox7 module regulates dwarfing by mediating the gibberellin pathway in apple.The Plant journal : for cell and molecular biology · 2026Article
- LsMAPK6 Phosphorylates the LsCO Protein to Enhance Its Stability and Transcriptional Activity, Promoting Floral Transition Upon High Temperatures in Lettuce.Plant biotechnology journal · 2026Article
- Unraveling the metabolic network and key bioactive compound accumulation during critical developmental stages ofFrontiers in plant science · 2026Article
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Authors and funding
13 authors.
Funding
Abstract
Lettuce is one of the most important vegetables worldwide. Bolting time is an important agronomic trait in lettuce production. Premature bolting reduces crop quality and marketability. Here, we genetically clone the LsBLH2 gene controlling bolting time in lettuce. LsBLH2 encodes a BEL1-like homeodomain protein. In the late bolting parent, the LsBLH2 had a 1-bp deletion in exon 1 which leads to a premature stop codon. CRISPR/cas9 knocking out and complementary tests showed that the loss-of-function of LsBLH2 delays bolting in lettuce. ChIP-seq, gene expression and phytohormone analysis showed that LsBLH2 regulates the gibberellin (GA) biosynthesis and metabolism. LsBLH2 binds to the promoter of the LsGA20ox1 and LsGA2ox8 and regulates their expression, leading to the bioactive GA accumulation during the vegetative-to-reproductive phase transition. Both LsOFP6 and LsKNAT3 interact with LsBLH2 and regulate bolting in a LsBLH2-dependent manner. LsOFP6 promotes, while LsKNAT3 suppresses the effects of LsBLH2 on GA biosynthesis during the transition and rosette stage in lettuce, respectively. In summary, the LsBLH2-LsOFP6-LsKANT3 module orchestrates bioactive GA accumulation to regulate bolting in lettuce, which provides insight into the bolting development process and offers new approaches for lettuce breeding to prevent premature bolting.
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Registered trials
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