ArticlePLoS biology2025
Repeated stress gradually impairs auditory processing and perception.
Article in PLoS biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- PAG-dependent defensive strategy selection: From stress-induced rigidity to adaptive flexibility.iScience · 2026Article
- Altered folate metabolism disrupts auditory function from neonatal vocalizations to adult perceptual precision.Journal of neurodevelopmental disorders · 2026Article
- Visual experience drives functional reorganization of cortical GABAergic circuits.bioRxiv : the preprint server for biology · 2026Article
- Tinnitus constancy and self-reported severe headache or migraine symptoms in peri- and postmenopausal women: a statistical modeling and machine learning analysis.European journal of medical research · 2025Observational
- Pathophysiological Insights and Multimodal Interventions in Chronic Tinnitus, Anxiety, and Sleep Disorders.Nature and science of sleep · 2025Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Repetitive stress, a common feature of modern life, is a major risk factor for psychiatric and sensory disorders. Despite the prevalence of perceptual abnormalities in these disorders, little is known about how repetitive stress affects sensory processing and perception. Here, we combine repetitive stress in mice, longitudinal measurement of cortical activity, and auditory-guided behaviors to test if sound processing and perception of neutral sounds in adults are modulated by repetitive stress. We found that repetitive stress alters sound processing, increasing spontaneous cortical activity while dampening sound-evoked responses in pyramidal and PV cells and heightening sound-evoked responses in SST cells. These alterations in auditory processing culminated in perceptual shifts, particularly a reduction in loudness perception. Additionally, our work reveals that the impact of stress on perception evolves gradually as the stressor persists over time, emphasizing the dynamic and evolving nature of this mechanism. Our findings provide insight into a possible mechanism by which repetitive stress alters sensory processing and behavior, challenging the idea that stress primarily modulates emotionally charged stimuli.
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