ArticleDiabetes care2025
Lung Function Impairment and Risks of Incident Cardiovascular Diseases and Mortality Among People With Type 2 Diabetes: A Prospective Cohort Study.
Article in Diabetes care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Effect of manual diaphragmatic release on ventilatory function and functional capacity in elderly type 2 diabetic women: A randomised controlled trial.Hong Kong physiotherapy journal : official publication of the Hong Kong Physiotherapy Association Limited = Wu li chih liao · 2026Article
- Oxidative stress-induced endothelial dysfunction drives mechanical and infectious lung injury: Therapeutic potential of kaempferol in males.Redox biology · 2026Article
- Small airways obstruction predicts cardiovascular disease incidence: a longitudinal study of UK Biobank.ERJ open research · 2026Article
- Lung function impairment and risk of sepsis and sepsis-related mortality: a large cohort study with over 310,000 participants.Science China. Life sciences · 2026Article
- Association of life's essential 8 with pulmonary function impairment: a cross-sectional analysis of the Kailuan study.Frontiers in nutrition · 2026Article
- A Machine Learning-Derived Risk Score Based on Dietary Nutrient Intake for Early Detection and Prognostic Prediction of Preserved Ratio Impaired Spirometry.International journal of chronic obstructive pulmonary disease · 2026Article
- Metabolomic profiling refines cardiovascular risk stratification beyond SCORE2-diabetes in patients with concurrent type 2 diabetes and pulmonary dysfunction.Frontiers in endocrinology · 2026Article
- Type 2 Diabetes Mellitus and Chronic Obstructive Pulmonary Disease - from Pathophysiology to Effective Management Overview.International journal of chronic obstructive pulmonary disease · 2026Review
- Nonlinear relationship between triglyceride-glucose index and cardiovascular mortality with competing risk analysis on populations aged 18-80 years.BMC cardiovascular disorders · 2025Article
- Cigarette Smoking-Induced Glucose Metabolic Reprogramming in Chronic Obstructive Pulmonary Disease: Mechanisms and Therapeutic Implications.International journal of chronic obstructive pulmonary disease · 2025Review
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Authors and funding
6 authors.
Funding
Abstract
objectiveIndividuals with type 2 diabetes (T2D) frequently exhibit impaired lung function, potentially accelerating the onset of cardiovascular disease (CVD), although prospective studies remain limited. We aimed to explore the relationship between lung function impairment and risk of CVD and mortality within this high-risk population. RESEARCH DESIGN AND
methodsThis prospective study included 16,242 participants with T2D and free of CVD from the UK Biobank. Obstructive physiology (OP), restrictive physiology (RP), and preserved ratio impaired spirometry (PRISm) were defined using spirometry, including forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC). Fine-Gray subdistribution hazards models and Cox proportional hazards models were used to estimate risks of CVD and all-cause mortality, respectively.
resultsDuring a median follow-up of 13.9 years, 2,825 incident cases of CVD and 2,811 deaths were documented. Lower FEV1, FVC, FEV1/FVC ratio, FEV1 percent predicted, and FVC percent predicted were related to higher risks of CVD and all-cause mortality. Compared with preserved lung function, the adjusted subdistribution hazard ratios (HRs) for CVD were 1.19 (95% CI 1.05-1.35) for OP and 1.47 (95% CI 1.33-1.65) for RP. Compared with the control group, the subdistribution HRs for CVD were 1.20 (95% CI 1.06-1.36) for OP and 1.43 (95% CI 1.29-1.59) for PRISm. These associations were consistent across subgroups and sensitivity analyses. Adding lung function measurements significantly enhanced the performance of CVD prediction beyond the SCORE2-Diabetes model.
conclusionsLung function impairment was associated with increased risks of CVD and all-cause mortality among individuals with T2D.
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